| Synthesis and characterization of novel PUFA esters exhibiting potential anticancer activities: An in vitro study. | |
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MedLine Citation:
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PMID: 21868138 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Polyunsaturated fatty acids (PUFAs) have been reported to play a regulatory role in tumour growth progression. In the present study, we have synthesized ester derivatives of two important PUFA viz., linoleic acid (LA) and arachidonic acid (AA) with propofol, a widely used general anaesthetic-sedative agent. The novel propofol ester analogues have been found to inhibit various cancer cell lines in a dose-dependent manner. Moreover, the compounds have been found to induce apoptotic cell death by enhancing the release of cytochrome c and expression of caspase-3. The data of the present study suggest that novel propofol-PUFA esters have strong potential to emerge as effective anticancer agents. |
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Authors:
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Azmat Ali Khan; Mahboob Alam; Saba Tufail; Jamal Mustafa; Mohammad Owais |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-3 |
Journal Detail:
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Title: European journal of medicinal chemistry Volume: - ISSN: 1768-3254 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0420510 Medline TA: Eur J Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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