Document Detail


Synthesis and characterization of a novel gadolinium-based contrast agent for magnetic resonance imaging of myelination.
MedLine Citation:
PMID:  23311333     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myelin is a membrane system that fosters nervous impulse conduction in the vertebrate nervous system. Myelin sheath disruption is a common characteristic of several neurodegenerative diseases such as multiple sclerosis (MS) and various leukodystrophies. To date, the diagnosis of MS is obtained using a set of criteria in which MRI observations play a central role. However, because of the lack of specificity for myelin integrity, the use of MRI as the primary diagnostic tool has not yet been accepted. In order to improve MR specificity, we began developing MR probes targeted toward myelin. In this work we describe a new myelin-targeted MR contrast agent, Gd-DODAS, based on a stilbene binding moiety and demonstrate its ability to specifically bind to myelin in vitro and in vivo. We also present evidence that Gd-DODAS generates MR contrast in vivo in T1-weighed images and in T1 maps that correlates to the myelin content.
Authors:
Luca Frullano; Junqing Zhu; Robert H Miller; Yanming Wang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-02-18
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  56     ISSN:  1520-4804     ISO Abbreviation:  J. Med. Chem.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-07-11     Completed Date:  2013-07-31     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1629-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism
Contrast Media / chemical synthesis*,  chemistry,  metabolism
Coordination Complexes / chemical synthesis*,  chemistry,  metabolism
Gadolinium*
Injections, Intraventricular
Magnetic Resonance Imaging
Mice
Mice, Inbred C57BL
Mice, Transgenic
Myelin Sheath / metabolism*
Rats
Rats, Sprague-Dawley
Spinal Cord / metabolism
Stereoisomerism
Grant Support
ID/Acronym/Agency:
R01 NS061837/NS/NINDS NIH HHS; R01 NS061837/NS/NINDS NIH HHS; R21 NS054109/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Coordination Complexes; 0/gadolinium (E)-2,2',2''-(10-(2-((3-(4-((4-(4-(methylamino)styryl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)propyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acetate; AU0V1LM3JT/Gadolinium
Comments/Corrections

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