| Synthesis and characterization of long-chain tartaric acid diamides as novel ceramide-like compounds. | |
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MedLine Citation:
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PMID: 20335949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ceramides play a crucial role in the barrier function of the skin as well as in transmembrane signaling. In this study long aliphatic chain tartaric acid diamides able to replace ceramides in an in vitro model of the stratum corneum lipid matrix due to their similar physico-chemical properties were synthesized from diacetoxysuccinic anhydride in four steps. Their pro-apoptotic effect on fibroblast cells was also investigated. |
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Authors:
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Bálint Sinkó; Melinda Pálfi; Szabolcs Béni; József Kökösi; Krisztina Takács-Novák |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-05 |
Journal Detail:
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Title: Molecules (Basel, Switzerland) Volume: 15 ISSN: 1420-3049 ISO Abbreviation: Molecules Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-25 Completed Date: 2010-06-29 Revised Date: 2010-12-15 |
Medline Journal Info:
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Nlm Unique ID: 100964009 Medline TA: Molecules Country: Switzerland |
Other Details:
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Languages: eng Pagination: 824-33 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Chemistry, Semmelweis University, Hogyes E.u.9., Budapest H-1092, Hungary. sinbal@gytk.sote.hu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects Ceramides / chemical synthesis*, chemistry*, pharmacology Diamide / chemical synthesis*, chemistry*, pharmacology Fibroblasts / cytology, drug effects Mice Solvents Tartrates / chemical synthesis*, chemistry*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Ceramides; 0/Solvents; 0/Tartrates; 10465-78-8/Diamide; 526-83-0/tartaric acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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