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Synthesis, characterization, interaction with DNA and cytotoxicity of Pd(ii) and Pt(ii) complexes containing pyridine carboxylic acid ligands.
MedLine Citation:
PMID:  23334262     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Four metal complexes [Pd(L(1))Cl(2)·2H(2)O] (), [Pt(L(1))Cl(2)·2H(2)O] (), [Pd(L(2))Cl(2)·H(2)O] () and [Pt(L(2))Cl(2)·H(2)O] () (L(1) = 2,2'-bipyridyl-5,5'-dicarboxylic acid, L(2) = 2,2'-bipyridyl-4,4'-dicarboxylic acid) have been synthesized under hydrothermal conditions and fully characterized by IR and (1)H-NMR spectra, elemental analysis, and X-ray single crystal diffraction analysis. Interactions of these complexes with fish sperm DNA (FS-DNA) were investigated using UV-Vis absorption and fluorescence spectroscopic methods. Further insight was brought by quantum chemistry calculations by means of G03 package and taking B3LYP functional Lanl2dz Gen basis set. Agarose gel electrophoresis run on pBR322 plasmid DNA gave proof that all four complexes exhibit efficient DNA cleavage. Complexes manifested cytotoxic specificity and a significant cancer cell inhibitory rate. Independent apoptosis tests under the light microscope, performed on hematoxylin-eosin stained HeLa cells, evidenced morphological changes induced by all the complexes.
Authors:
Ya-Guang Sun; Di Sun; Wan Yu; Ming-Chang Zhu; Fu Ding; Yi-Nan Liu; En-Jun Gao; Shu-Ju Wang; Gang Xiong; Ileana Dragutan; Valerian Dragutan
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  Dalton transactions (Cambridge, England : 2003)     Volume:  -     ISSN:  1477-9234     ISO Abbreviation:  Dalton Trans     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101176026     Medline TA:  Dalton Trans     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratory of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China. yaguangsun@yahoo.com.cn.
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