Document Detail


Synthesis, characterization and in vitro assessment of the magnetic chitosan-carboxymethylcellulose biocomposite interactions with the prokaryotic and eukaryotic cells.
MedLine Citation:
PMID:  22884836     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Preparation and characterization of CS/Fe(3)O(4)/CMC composite scaffolds including the morphology, crystallinity, and the in vitro efficacy as antibiotic delivery vehicles as well as their influence on the eukaryotic cells are reported. The results demonstrated that the magnetic polymeric composite scaffolds are exhibiting structural and functional properties that recommend them for further applications in the biomedical field. They improve the activity of currently used antibiotics belonging to penicillins, macrolides, aminoglycosides, rifampicines and quinolones classes, representing potential macromolecular carriers for these antimicrobial substances, to achieve extracellular and intracellular targets. The obtained systems are not cytotoxic and do not influence the eukaryotic HCT8 cell cycle, representing potential tools for the delivery of drugs in a safe, effective and less expensive manner.
Authors:
Alexandru Mihai Grumezescu; Ecaterina Andronescu; Anton Ficai; Coralia Bleotu; Dan Eduard Mihaiescu; Mariana Carmen Chifiriuc
Related Documents :
22580906 - Development of cell lines from the cactophagous insect: cactoblastis cactorum (lepidopt...
22319516 - Kaposi's sarcoma associated herpesvirus entry into target cells.
20675176 - Mechanical design of an intracranial stent for treating cerebral aneurysms.
6033936 - Changes in the fine structure of bone cells after the administration of parathyroid ext...
18830616 - Quantitative microscopy and systems biology: seeing the whole picture.
19876846 - Xenopus development from late gastrulation to feeding tadpole in simulated microgravity.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-4
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  -     ISSN:  1873-3476     ISO Abbreviation:  Int J Pharm     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxidic Materials and Nanomaterials, Polizu Street no 1-7, 011061 Bucharest, Romania.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Blooming of Irganox 3114(®) antioxidant onto a medical grade elastomer. Impact of the recrystalliza...
Next Document:  Antisolvent crystallisation is a potential technique to prepare engineered lactose with promising ae...