| Synthesis and characterization of functionalized biodegradable poly(DL-lactide-co-RS-beta-malic acid). | |
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MedLine Citation:
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PMID: 18181093 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amorphous poly(DL-lactide-co-RS-beta-malic acid) (PDLLMAc) was synthesized by hydrogenolysis of poly(DL-lactide-co-RS-beta-malolactonate) (PDLLMA), which was obtained from the ring-opening polymerization of DL-lactide (DLLA) and RS-beta-benzyl malolactonate (MA) using stannous octoate as the catalyst. The amount of malolactonate (MA) in the feeding dose was varied from 0 to 8.0 mol %. The copolymers were characterized by 1H NMR, FTIR, GPC, and DSC. The tensile properties and water uptake of the copolymers were measured. The protective benzyl groups in PDLLMA were completely removed in hydrogenolysis to produce PDLLMAc. The molecular weight (M(n)) of the copolymers decreased with increasing MA content. However, with low feed MA content of 0.6 and 1.0%, high molecular weight PDLLMAc with M(n) of 63 and 35 kDa, respectively, were obtained; these copolymers exhibited good tensile yield stress and modulus of 17-23 MPa and 1.1-1.4 GPa, which are comparable to PDLLA homopolymer. The corresponding protected PDLLMA have tensile yield stress/modulus of 2.0-2.4 MPa and 11-42 MPa. The malic acid comonomer in PDLLMAc significantly improves the tensile strength and modulus compared to the protected PDLLMA. Further, the functionalizable PDLLMAc (with 0.6 mol % feed MA) was grafted with bioactive RGD peptide. The culture of primary umbilical artery smooth muscle cells was investigated. Methylthiazoletetrazolium results showed that both the RGD- and COOH-functionalized (0.6 mol %) PDLLMAc copolymers were significantly more biocompatible than the control PDLLA and could potentially be employed as tissue engineering scaffolds. |
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Authors:
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Bin He; Yin Fun Poon; Jie Feng; Mary B Chan-Park |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical materials research. Part A Volume: 87 ISSN: 1552-4965 ISO Abbreviation: - Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-01 Completed Date: 2008-11-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234237 Medline TA: J Biomed Mater Res A Country: United States |
Other Details:
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Languages: eng Pagination: 254-63 Citation Subset: IM |
Affiliation:
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School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Singapore. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorbable Implants Biocompatible Materials / chemistry*, pharmacology Cells, Cultured Humans Malates / chemistry*, pharmacology Materials Testing Molecular Weight Myocytes, Smooth Muscle / drug effects Oligopeptides / chemistry Polyesters / chemistry*, pharmacology Tensile Strength Water |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Malates; 0/Oligopeptides; 0/Polyesters; 0/poly(L-lactide-co-beta-malic acid); 7732-18-5/Water; 99896-85-2/arginyl-glycyl-aspartic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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