| Synthesis and characterization of cholesterol-poly(ethylene glycol)-poly(D,L-lactic acid) copolymers for promoting osteoblast attachment and proliferation. | |
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MedLine Citation:
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PMID: 16977387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel cholesterol-poly(ethylene glycol)-poly(D,L-lactic acid) copolymer (CPEG-PLA) has been synthesized as a potential surface additive for promoting osteoblast attachment and proliferation. The gel permeation chromatography (GPC) and nuclear magnetic resonance spectroscopy (NMR) results indicated the product had expected structure with low polydispersities in the range of 1.1-1.5. By blending the poly(D,L-lactic acid) (PLA) with CPEG-PLA, the surface of modified PLA membrane was investigated by atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS) and contact angle. The results revealed the enrichment of PEG chain on the surface. Osteoblast cell line (MC3T3) was chosen to test the cell behavior on modified PLA membranes. The osteoblast test about cell attachment, proliferation, cell viability and cell morphology investigation on CPEG-PLA modified PLA substrates showed the CPEG-PLA with 15 and 5 ethylene glycol units promoted osteoblast attachment and growth, while the CPEG-PLA with 30 ethylene glycol units prevent osteoblast adhesion and proliferation. This simple surface treatment method may have potentials for tissue engineering and other biomedical applications. |
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Authors:
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Guanhua Yu; Jian Ji; Jiacong Shen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of materials science. Materials in medicine Volume: 17 ISSN: 0957-4530 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-15 Completed Date: 2006-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: United States |
Other Details:
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Languages: eng Pagination: 899-909 Citation Subset: IM |
Affiliation:
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Department of Polymer Science and Engineering, Key Laboratory of Macromolecule Synthesis and Functionalization, Ministry of Education, Zhejiang University, Hangzhou 310027, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3T3 Cells Animals Biocompatible Materials / chemical synthesis* Cell Adhesion Cell Proliferation Cholesterol* Lactates* Mice Osteoblasts* Polyethylene Glycols* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Lactates; 0/Polyethylene Glycols; 0/poly(lactic acid-ethylene glycol); 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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