| Synthesis, characterization and biological evaluation of some novel 17-isoxazoles in the estrone series. | |
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MedLine Citation:
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PMID: 22613036 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Regioselective 1,3-dipolar cycloadditions of different aryl nitrile oxides to mestranol were carried out to furnish novel steroidal 17α-isoxazoles in good to excellent yields. Copper(I) was found to be an efficient catalyst, accelerating the intermolecular ring-closures and leading exclusively to 3,5-disubstituted isoxazoles. The yields of the cycloadducts, however, were influenced by the substituents on the aromatic moiety of the 1,3-dipoles. Moreover, dehydration of the primary products resulted in the corresponding Δ(16,17)exo-heterocyclic derivatives. All the synthesized compounds were subjected to in vitro pharmacological studies of their antiproliferative effects relative to three human malignant cell lines (HeLa, MCF7 and A2780). |
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Authors:
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Dóra Kovács; Zalán Kádár; Gergő Mótyán; Gyula Schneider; János Wölfling; István Zupkó; Eva Frank |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-18 |
Journal Detail:
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Title: Steroids Volume: - ISSN: 1878-5867 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404536 Medline TA: Steroids Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
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Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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