Document Detail

Synthesis, characterization and biodistribution of new fatty acids conjugates bearing N,N,N-donors incorporated [(99m)Tc/Re(CO)(3)](+).
MedLine Citation:
PMID:  23321775     Owner:  NLM     Status:  Publisher    
[(99m)Tc(CO)(3)](+)-6-[N-(2-dipicolyl)amino]hexanoic acid () and [(99m)Tc(CO)(3)](+)-11-[N-(2-dipicolyl)amino]undecanoic acid () were prepared by incorporating [(99m)Tc-(CO)(3)](+) into 6-[N-(2-dipicolyl)amino]hexanoic acid and 11-[N-(2-dipicolyl)amino]undecanoic acid, respectively. The overall radiochemical yield of and was from 79.7% to 91.3% and radiochemical purity after HPLC purification was more than 94%. The resulting complexes were found to be chemically stable when incubated in SD rat serum for 3 h at 37 °C. Tissue distribution studies in normal mice showed that high initial uptake of Tc-99m complexes were observed, followed by slow clearance from the heart. The maximum heart-to-blood ratio of was 1.46 at 60 min, but showed a poor heart-to-blood ratio. By estimating the tissue distribution and the computing result of the molar volume and the solvation free energy of Tc-99m chelating groups, a small-size and monocationic Tc-99m core is very important to enhance the myocardial accumulation and low liver uptake for the fatty acid tracers.
Huahui Zeng; Lingzhou Zhao; Shiyuan Hu; Yongjuan Liu; Haijing Yu; Na Chen; Huabei Zhang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  Dalton transactions (Cambridge, England : 2003)     Volume:  -     ISSN:  1477-9234     ISO Abbreviation:  Dalton Trans     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101176026     Medline TA:  Dalton Trans     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China.
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