| Synthesis, characterization and bioactive evaluation of copper(II) 5,10,15,20-tetrakis[alpha,alpha,alpha,alpha-2-(2,6-bis(4-methylpiperazine-1-yl-methyl)-4-iminomethyl phenol)phenyl] porphyrin: a picket-fence porphyrin. | |
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MedLine Citation:
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PMID: 20678957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We are interested in constructing deeper small cavities by adding more bulky substituents at the ortho-phenyl positions of tetrakis(o-aminophenyl)porphyrin. The synthesis of picket-fence porphyrin is initiated by the preparation of the tetrakis(o-nitrophenyl)porphyrin followed by the nitro to amino reduction and subsequent condensation with Schiff base ligand to form imine linkages of porphyrin complexes. The synthesis and characterization of a new series of picket-fence porphyrins and their copper complexes are described. 5,10,15,20-Tetrakis[alpha,alpha,alpha,alpha-2-(2,6-bis(4-methyl piperazine-1-yl-methyl)-4-iminomethyl phenol)phenyl] porphyrin can be synthesized from 2,6-bis[4-methylpiperazin-1-yl-methyl]-4-formylphenol (L) and 5,10,15,20-tetra[alpha,alpha,alpha,alpha-o-nitropheny1]-porphyrin. 5,10,15,20-Tetra[alpha,alpha,alpha,alpha-o-aminopheny1]-porphyrin was obtained by the reduction of 5,10,15,20-tetra[alpha,alpha,alpha,alpha-o-nitropheny1]-porphyrin. The spectral, electrochemical, antibacterial, antifungal and cytotoxicity properties of all the picket-fence porphyrin complexes were characterized and studied. |
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Authors:
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K Rajesh; A Kalilur Rahiman; K Shanmuga Bharathi; S Sreedaran; V Gangadevi; V Narayanan |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-13 |
Journal Detail:
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Title: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Volume: 77 ISSN: 1873-3557 ISO Abbreviation: Spectrochim Acta A Mol Biomol Spectrosc Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-23 Completed Date: 2010-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602533 Medline TA: Spectrochim Acta A Mol Biomol Spectrosc Country: England |
Other Details:
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Languages: eng Pagination: 652-60 Citation Subset: IM |
Affiliation:
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Department of Inorganic Chemistry, University of Madras, Chennai, Tamil Nadu, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents
/
chemical synthesis,
chemistry*,
pharmacology Apoptosis / drug effects Aspergillus niger / drug effects Candida albicans / drug effects Cell Line, Tumor / drug effects, ultrastructure Coordination Complexes / chemical synthesis, chemistry*, pharmacology Disk Diffusion Antimicrobial Tests Drug Evaluation, Preclinical Drug Screening Assays, Antitumor Electrochemical Techniques Gram-Negative Bacteria / drug effects Humans Metalloporphyrins / chemical synthesis, chemistry*, pharmacology Microbial Sensitivity Tests Molecular Structure Oxidation-Reduction Piperazines / chemical synthesis, chemistry*, pharmacology Spectrometry, Fluorescence Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Infrared Staphylococcus aureus / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Coordination Complexes; 0/Metalloporphyrins; 0/Piperazines; 0/copper(II) 5,10,15,20-tetrakis(alpha,alpha,alpha,alpha-2-(2,6-bis(4-methylpiperazine-1-ylmethyl)-4-iminomethylphenol)phenyl)porphyrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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