| Synthesis and characterization of arginine-glycine-aspartic peptides conjugated poly(lactic acid-co-L-lysine) diblock copolymer. | |
| | |
MedLine Citation:
|
PMID: 17705054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A biodegradable Copolymer of poly(lactic acid-co-lysine)(PLA-PLL) was synthesized by a modified method and novel Arginine-Glycine-Aspartic (RGD) peptides were chemical conjugated to the primary epsilon-amine groups of lysine components in four steps: I to prepare the monomer of 3-(Nepsilon-benzoxycarbonyl-L-lysine)-6-L-methyl-2,5-morpholinedione; II to prepare diblock copolymer poly(lactic acid-co-(Z)-L-lysine) (PLA-PLL(Z)) by ring-opening polymerization of monomer and L,L-lactide with stannous octoate as initiator; III to prepare diblock copolymer PLA-PLL by deprotected the copolymer PLA-PLL(Z) in HBr/HoAc solution; IV the reaction between RGD and the primary epsilon-amine groups of the PLA-PLL. The structure of PLA-PLL-RGD and its precursors were conformed by FTIR-Raman and 1H NMR. Low weight average molecular weight (9,200 g/mol) of the PLA-PLL was obtained and its PDI is 1.33 determined by GPC. The PLA-PLL contained 2.1 mol% lysine groups as determined by 1H NMR using the lysine protecting group's phenyl protons. Therefore, the novel RGD-grafted diblock copolymer is expected to find application in drug carriers for tumor therapy or non-viral DNA carriers for gene therapy. |
| | |
Authors:
|
Hui Yu; Xiaojuan Guo; Xueliang Qi; Peifeng Liu; Xinyuan Shen; Yourong Duan |
Related Documents
:
|
9503624 - Poly-beta-hydroxybutyrate production by lactic acid bacteria. 20227474 - Preparation and evaluation of biodegradable microspheres containing a new potent osteog... 7948574 - Poly[(amino acid ester)phosphazenes] as substrates for the controlled release of small ... 17321084 - Controlled protein release from electrospun biodegradable fiber mesh composed of poly(e... 2990854 - Purification of thyroid lysosomes by colloidal silica density gradient centrifugation. 4058264 - Fatty acids and fatty alcohols of wax esters in the orange roughy: specific textures of... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-08-20 |
Journal Detail:
|
Title: Journal of materials science. Materials in medicine Volume: 19 ISSN: 0957-4530 ISO Abbreviation: J Mater Sci Mater Med Publication Date: 2008 Mar |
Date Detail:
|
Created Date: 2008-02-29 Completed Date: 2008-07-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9013087 Medline TA: J Mater Sci Mater Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1275-81 Citation Subset: IM |
Affiliation:
|
State Key Lab for Modification of Chemical Fibers & Polymer Materials, College of Materials Science & Engineering, Donghua University, Shanghai 200051, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Arginine
/
chemistry* Aspartic Acid / chemistry* Cyclization Glycine / chemistry* Lactic Acid / chemistry* Models, Biological Peptides / chemistry Polylysine / chemistry* Polymers / chemical synthesis*, chemistry Spectrum Analysis |
| Chemical | |
Reg. No./Substance:
|
0/Peptides; 0/Polymers; 25104-18-1/Polylysine; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid; 56-40-6/Glycine; 56-84-8/Aspartic Acid; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of mean platelet volume in triagging acute coronary syndromes.
Next Document: Poly(2-hydroxyethyl methacrylate) emboli with increased haemostatic effect for correction of haemorr...