Document Detail


Synthesis and characterization of arginine-glycine-aspartic peptides conjugated poly(lactic acid-co-L-lysine) diblock copolymer.
MedLine Citation:
PMID:  17705054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A biodegradable Copolymer of poly(lactic acid-co-lysine)(PLA-PLL) was synthesized by a modified method and novel Arginine-Glycine-Aspartic (RGD) peptides were chemical conjugated to the primary epsilon-amine groups of lysine components in four steps: I to prepare the monomer of 3-(Nepsilon-benzoxycarbonyl-L-lysine)-6-L-methyl-2,5-morpholinedione; II to prepare diblock copolymer poly(lactic acid-co-(Z)-L-lysine) (PLA-PLL(Z)) by ring-opening polymerization of monomer and L,L-lactide with stannous octoate as initiator; III to prepare diblock copolymer PLA-PLL by deprotected the copolymer PLA-PLL(Z) in HBr/HoAc solution; IV the reaction between RGD and the primary epsilon-amine groups of the PLA-PLL. The structure of PLA-PLL-RGD and its precursors were conformed by FTIR-Raman and 1H NMR. Low weight average molecular weight (9,200 g/mol) of the PLA-PLL was obtained and its PDI is 1.33 determined by GPC. The PLA-PLL contained 2.1 mol% lysine groups as determined by 1H NMR using the lysine protecting group's phenyl protons. Therefore, the novel RGD-grafted diblock copolymer is expected to find application in drug carriers for tumor therapy or non-viral DNA carriers for gene therapy.
Authors:
Hui Yu; Xiaojuan Guo; Xueliang Qi; Peifeng Liu; Xinyuan Shen; Yourong Duan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-20
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  19     ISSN:  0957-4530     ISO Abbreviation:  J Mater Sci Mater Med     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-29     Completed Date:  2008-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1275-81     Citation Subset:  IM    
Affiliation:
State Key Lab for Modification of Chemical Fibers & Polymer Materials, College of Materials Science & Engineering, Donghua University, Shanghai 200051, China.
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MeSH Terms
Descriptor/Qualifier:
Arginine / chemistry*
Aspartic Acid / chemistry*
Cyclization
Glycine / chemistry*
Lactic Acid / chemistry*
Models, Biological
Peptides / chemistry
Polylysine / chemistry*
Polymers / chemical synthesis*,  chemistry
Spectrum Analysis
Chemical
Reg. No./Substance:
0/Peptides; 0/Polymers; 25104-18-1/Polylysine; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid; 56-40-6/Glycine; 56-84-8/Aspartic Acid; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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