| Synthesis, characterization, antitumoral and osteogenic activities of quercetin vanadyl(IV) complexes. | |
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MedLine Citation:
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PMID: 16821038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of new vanadium derivatives with organic ligands, which improve the beneficial actions (insulin-mimetic, antitumoral) and decrease the toxic effects, is of great interest. A good candidate for the generation of a new vanadium compound is the flavonoid quercetin because of its own anticarcinogenic effect. The complex [VO(Quer)(2)EtOH]( n ) (QuerVO) has been synthesized and characterized by means of different spectroscopic techniques (UV-vis, Fourier transform IR, electron paramagnetic resonance) and its magnetic and stability properties. The inhibitory effect on bovine alkaline phosphatase (ALP) activity has been tested for the free ligand, the complex as well as for the vanadyl(IV) (comparative purposes). The biological activity of the complex on the proliferation of two osteoblast-like cells in culture, a normal one (MC3T3E1) and a tumoral one (UMR106), has been compared with that of the vanadyl(IV) cation and quercetin. The differentiation osteoblast markers ALP specific activity and collagen synthesis have been also tested. In addition, the effect of QuerVO on the activation of the extracellular regulated kinase (ERK) pathway is reported. The bone antitumoral effect of quercetin alone was established with the cell proliferation assays (it inhibits the proliferation of the tumoral cells and does not exert any effect on the normal osteoblasts). Moreover, the complex exerts osteogenic effects since it stimulates the type I collagen production and is a weak inhibitory agent upon ALP activity. Finally, QuerVO stimulated the ERK phosphorylation in a dose-response manner and this activation seems to be involved as one of the possible mechanisms for the biological effects of the complex. |
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Authors:
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Evelina G Ferrer; María V Salinas; María J Correa; Luciana Naso; Daniel A Barrio; Susana B Etcheverry; Luis Lezama; Teófilo Rojo; Patricia A M Williams |
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Publication Detail:
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Type: Historical Article; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-07-05 |
Journal Detail:
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Title: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry Volume: 11 ISSN: 0949-8257 ISO Abbreviation: J. Biol. Inorg. Chem. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-07-21 Completed Date: 2006-09-27 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9616326 Medline TA: J Biol Inorg Chem Country: Germany |
Other Details:
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Languages: eng Pagination: 791-801 Citation Subset: IM |
Affiliation:
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CEQUINOR (Centro de Química Inorgánica), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, 1900 La Plata, Argentina. |
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| MeSH Terms | |
Descriptor/Qualifier:
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3T3-L1 Cells Alkaline Phosphatase / metabolism Animals Antineoplastic Agents / chemical synthesis*, chemistry, pharmacology* Blotting, Western Cell Proliferation Electron Spin Resonance Spectroscopy Extracellular Signal-Regulated MAP Kinases / metabolism History, 20th Century Intestines / enzymology Mice Osteogenesis / drug effects* Quercetin / chemistry* Spectrophotometry, Ultraviolet Spectroscopy, Fourier Transform Infrared Vanadium / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 117-39-5/Quercetin; 7440-62-2/Vanadium; EC 2.7.11.24/Extracellular Signal-Regulated MAP Kinases; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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