Document Detail

Synthesis, characterization and antifungal activity of quaternary derivatives of chitosan on Aspergillus flavus.
MedLine Citation:
PMID:  22819383     Owner:  NLM     Status:  Publisher    
Two series of new chitosan derivatives were synthesized by reaction of deacetylated chitosan (CH) with propyl (CH-Propyl) and pentyl (CH-Pentyl) trimethylammonium bromides to obtain derivatives with increasing degrees of substitution (DS). The derivatives were characterized by (1)H NMR and potentiometric titration techniques and their antifungal activities on the mycelial growth of Aspergillus flavus were investigated in vitro. The antifungal activities increase with DS and the more substituted derivatives of both series, CH-Propyl and CH-Pentyl, exhibited antifungal activities respectively three and six times higher than those obtained with commercial and deacetylated chitosan. The minimum inhibitory concentrations (MIC) were evaluated at 24, 48 and 72h by varying the polymer concentration from 0.5 to 16g/L and the results showed that the quaternary derivatives inhibited the fungus growth at polymer concentrations four times lower than that obtained with deacetylated chitosan (CH). The chitosans modified with pentyltrimethylammonium bromide exhibited higher activity and results are discussed taking into account the degree of substitution (DS).
Rafael de Oliveira Pedro; Mirelle Takaki; Teresa Cristina Castilho Gorayeb; Vanildo Luiz Del Bianchi; João Cláudio Thomeo; Marcio José Tiera; Vera Aparecida de Oliveira Tiera
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-20
Journal Detail:
Title:  Microbiological research     Volume:  -     ISSN:  1618-0623     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9437794     Medline TA:  Microbiol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier GmbH. All rights reserved.
Department of Chemistry and Environmental Sciences, Institute of Biosciences, Humanities and Exact Sciences - IBILCE, São Paulo State University - UNESP, São José do Rio Preto, São Paulo, Brazil.
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