| Synthesis, characterization and antifungal activities of some benzenesulphonylamino acid derivatives. | |
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MedLine Citation:
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PMID: 12481383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Condensation of benzenesulphonyl chloride (1) with a series of amino acids afforded benzenesulphonylamino acids (2a-d). Esterification of the derivatives (2a-d) in methanol gave the corresponding benzensulphonylamino acid methylesters (3a-d), which condensed with o-aminophenol and o-phenylene diamine to give the benzoxazoles (4a-d) and benximidazoles (5a-d) respectively. Hydrazinolysis of the methyl esters (3a-d) afforded the hydrazide derivatives (6a-d). The 1,2-diazeridine derivatives (7a-d) can be prepared by the reaction of hydrazides (6a-d) with alpha-chloroacetylchloide. Schiff's bases (10a-d) were achieved by the condensation of p-chlorobenzaldehyde with the hydrazides (6a-d). Condensation of Schiff's bases (10a-d) with p-chlorophenyldiazonium chloride afforded the formazan derviatives (11a-d). The hydrazides (6a-d) were reacted with acetylethylacetate to give 3-methyl-2-pyrazoline-2-one derivatives (8a-d), which condensed with p-chlorobenzaldehyde to give 4-arylidino-3-methyl-2-pyrazoline-2-one derivatives (9a-d). All derivatives (2-11) were tested against: A. flavus, A. parasiticus, A. alutaceus and F. moniliforme. Some of the derivatives showed promising results against the tested fungi. |
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Authors:
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S A Abdel-Ghaffar; G B Mpango; M A Ismail; S K Nanyonga |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bollettino chimico farmaceutico Volume: 141 ISSN: 0006-6648 ISO Abbreviation: Boll Chim Farm Publication Date: 2002 Sep-Oct |
Date Detail:
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Created Date: 2002-12-16 Completed Date: 2003-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372534 Medline TA: Boll Chim Farm Country: Italy |
Other Details:
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Languages: eng Pagination: 389-93 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Makerere University, Kampala, Uganda. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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chemical synthesis*,
pharmacology* Antifungal Agents / chemical synthesis*, pharmacology* Benzenesulfonates / chemical synthesis*, pharmacology* Fungi / drug effects* Indicators and Reagents Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Pyrazoles / chemical synthesis*, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Antifungal Agents; 0/Benzenesulfonates; 0/Indicators and Reagents; 0/Pyrazoles |
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