Document Detail


Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine.
MedLine Citation:
PMID:  20171099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Analogues of the antifungal marine natural product (E)-dysidazirine were prepared and evaluated in broth ro-dilution assays against a panel of fungal pathogens. A simple structure-activity relationship was developed which provides insight into the mechanism of action of long-chain 2H-azirine carboxylates.
Authors:
Colin K Skepper; Doralyn S Dalisay; Tadeusz F Molinski
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-02-01
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  20     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-07-13     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  2029-32     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / chemical synthesis*,  pharmacology*
Azirines / chemistry*
Carboxylic Acids / chemical synthesis*,  pharmacology*
Esters
Microbial Sensitivity Tests
Grant Support
ID/Acronym/Agency:
AI 039987/AI/NIAID NIH HHS; R01 AI039987/AI/NIAID NIH HHS; R01 AI039987-11/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Azirines; 0/Carboxylic Acids; 0/Esters; 113507-74-7/dysidazirine
Comments/Corrections

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