Document Detail


Synthesis of a carboxylate functionalized bis-amino acid monomer.
MedLine Citation:
PMID:  19391596     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synthesis of the first functionalized bis-amino acid monomer proAc(2S3S4R) 1 that carries an acetyl side chain is presented. This monomer was incorporated into oligomer 3 and the solution phase structure was determined by using two-dimensional nuclear magnetic resonance. The solution structure confirmed the intended connectivity and stereochemistry of the oligomer. This first functionalized bis-amino acid represents a milestone toward functionalized bis-peptide nanostructures for catalytic, molecular recognition, and nanotechnology applications.
Authors:
Sharad Gupta; Christian E Schafmeister
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  74     ISSN:  1520-6904     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-08     Completed Date:  2009-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3652-8     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
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MeSH Terms
Descriptor/Qualifier:
Amides / chemistry
Amino Acids / chemical synthesis*,  chemistry
Carboxylic Acids / chemistry*
Esters / chemistry
Models, Molecular
Molecular Conformation
Solvents / chemistry
Grant Support
ID/Acronym/Agency:
GM067866/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Amides; 0/Amino Acids; 0/Carboxylic Acids; 0/Esters; 0/Solvents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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