Document Detail

Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques.
MedLine Citation:
PMID:  12945889     Owner:  NLM     Status:  MEDLINE    
Methods to allow the clean preparation of oligosaccharides were investigated using techniques that do not require conventional column chromatography or an aqueous work-up. The route was designed to provide rapid access to oligosaccharides and is suitable for automation and parallel library formation. The research has focused on the glycosidations of a range of glycosyl acceptors with various selenophenyl glycosyl donors using iodine as an activator in the presence of DTBMP, a hindered organic base. Hydroxyl-containing contaminants were removed by scavenging with polymer-supported tosyl chloride.
Rachel N MacCoss; Paul E Brennan; Steven V Ley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  1     ISSN:  1477-0520     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-08-29     Completed Date:  2004-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  2029-31     Citation Subset:  IM    
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
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MeSH Terms
Carbohydrate Sequence
Combinatorial Chemistry Techniques / methods*
Glycosides / chemistry
Iodine / chemistry
Molecular Sequence Data
Oligosaccharides / chemical synthesis*,  chemistry
Tosyl Compounds / chemistry
Reg. No./Substance:
0/Glycosides; 0/Oligosaccharides; 0/Tosyl Compounds; 7553-56-2/Iodine

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