| Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques. | |
| | |
MedLine Citation:
|
PMID: 12945889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Methods to allow the clean preparation of oligosaccharides were investigated using techniques that do not require conventional column chromatography or an aqueous work-up. The route was designed to provide rapid access to oligosaccharides and is suitable for automation and parallel library formation. The research has focused on the glycosidations of a range of glycosyl acceptors with various selenophenyl glycosyl donors using iodine as an activator in the presence of DTBMP, a hindered organic base. Hydroxyl-containing contaminants were removed by scavenging with polymer-supported tosyl chloride. |
| | |
Authors:
|
Rachel N MacCoss; Paul E Brennan; Steven V Ley |
Related Documents
:
|
10628569 - A rapid and simple sep pak method for purification of radioiodinated iqnp, a high affin... 8141729 - A comparison of three isolation methods for obtaining immunoglobulin a from turkey bile. 21956149 - High throughput plasma n-glycome profiling using multiplexed labelling and uplc with fl... 17289059 - Supercritical fluid extraction of quinolizidine alkaloids from sophora flavescens ait. ... 7849489 - Large-scale synthesis, purification, and analysis of oligodeoxynucleotide phosphorothio... 16259569 - Serotype specificity of adenovirus purification using anion-exchange chromatography. 22876599 - High-performance liquid chromatographic determination of alpha-tocopherol in inclusion ... 1248119 - An integrated approach to lipid profiling: enzymatic determination of cholesterol and t... 18810859 - Associations between the presence and magnitude of escherichia coli o157 in feces at ha... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Organic & biomolecular chemistry Volume: 1 ISSN: 1477-0520 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2003 Jun |
Date Detail:
|
Created Date: 2003-08-29 Completed Date: 2004-02-02 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: England |
Other Details:
|
Languages: eng Pagination: 2029-31 Citation Subset: IM |
Affiliation:
|
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Carbohydrate Sequence Combinatorial Chemistry Techniques / methods* Glycosides / chemistry Glycosylation Iodine / chemistry Molecular Sequence Data Oligosaccharides / chemical synthesis*, chemistry Tosyl Compounds / chemistry |
| Chemical | |
Reg. No./Substance:
|
0/Glycosides; 0/Oligosaccharides; 0/Tosyl Compounds; 7553-56-2/Iodine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The tethered aminohydroxylation (TA) reaction.
Next Document: Substrate control of stereoselection in the rhodium(I) catalyzed intramolecular [4 + 2] cycloadditio...