| Synthesis of boronic acid derivatives of tyropeptin: proteasome inhibitors. | |
| | |
MedLine Citation:
|
PMID: 19307118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Boronic acid derivatives of tyropeptin were synthesized with TP-110 as the lead compound. Due to the lability of the aminoboronic acid moiety, careful design of the deprotection and coupling sequence was required. Liquid-liquid partition chromatography was found to be a powerful tool for purification of compounds of this class. The obtained derivatives showed potent inhibitory activities against the human 20S proteasome in vitro. |
| | |
Authors:
|
Takumi Watanabe; Isao Momose; Masatoshi Abe; Hikaru Abe; Ryuichi Sawa; Yoji Umezawa; Daishiro Ikeda; Yoshikazu Takahashi; Yuzuru Akamatsu |
Related Documents
:
|
11325428 - Competitive sorption of platinum and palladium on chitosan derivatives. 20726008 - Synthesis and anticancer activity of novel betulinic acid and betulin derivatives. 18963798 - Characteristics of industrial di(alkylphenyl)dithiophosphoric acids. 12922158 - Preparation of liposomes with glucose binding sites: liposomes containing di-branched a... 1987808 - Effect of udca on intracellular and biliary ph in isolated rat hepatocyte couplets and ... 23535338 - Lipid status of the two high latitude fish species, leptoclinus maculatus and lumpenus ... |
Publication Detail:
|
Type: Comparative Study; Journal Article Date: 2009-03-04 |
Journal Detail:
|
Title: Bioorganic & medicinal chemistry letters Volume: 19 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-04-03 Completed Date: 2009-08-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
|
Languages: eng Pagination: 2343-5 Citation Subset: IM |
Affiliation:
|
Molecular Structure Research Group, Microbial Chemistry Research Center, Tokyo, Japan. twatanabe@bikaken.or.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Boronic Acids
/
chemical synthesis*,
pharmacology Cell Line, Tumor Dipeptides / chemical synthesis*, pharmacology Humans Oligopeptides / chemistry, pharmacology Protease Inhibitors / chemical synthesis*, pharmacology Proteasome Endopeptidase Complex / antagonists & inhibitors*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/1-naphthylacetyl-(O-methyl)-tyrosyl-valyl-(O-methyl)-tyrosinal; 0/Boronic Acids; 0/Dipeptides; 0/Oligopeptides; 0/Protease Inhibitors; 0/tyropeptin A; 0/tyropeptin B; EC 3.4.25.1/Proteasome Endopeptidase Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Facile synthesis of de-O-sulfated salacinols: revision of the structure of neosalacinol, a potent al...
Next Document: Quality of practice in an intensive care unit (ICU): a mini-ethnographic case study.