Document Detail

Synthesis of bioreducible and acid labile poly(amido amine)s via Michael-addition reactions and their application in gene delivery.
MedLine Citation:
PMID:  22195836     Owner:  NLM     Status:  In-Data-Review    
Reducible poly(amido amine)s (HPAAs) with acid labile groups have been prepared via Michael addition polymerization. These PAAs are very sensitive to reducing agents such as dithiothreitol (DTT) and glutathione (GSH), and sensitive to pH. The polymers show good condensing property for DNA and good gene transfection efficiency.
Zhiqiang Yu; Junjie Yan; Yezi You
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of controlled release : official journal of the Controlled Release Society     Volume:  152 Suppl 1     ISSN:  1873-4995     ISO Abbreviation:  J Control Release     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607908     Medline TA:  J Control Release     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  e179-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
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