| Synthesis and biological evaluation of a technetium-99m(I)-tricarbonyl-labelled phenyltropane derivative. | |
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MedLine Citation:
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PMID: 16271471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new tropane derivative was synthesized by combining a tridentate ligand, N-(2-picolylamine)-N-acetic acid (2-PAA), and a phenyltropane derivative. It was labelled with a [(99m)Tc(CO)(3)](+) moiety, resulting in the formation of two stable and neutral lipophilic isomers. Their identity was confirmed using radio-LC-MS. In normal mice, no brain uptake was observed for any of the isomers and in vitro autoradiography using mouse brain sections showed no specific uptake in the striatal area. |
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Authors:
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Davy M Kieffer; Bernard J Cleynhens; Hubert P Vanbilloen; Dirk Rattat; Christelle Y Terwinghe; Luc Mortelmans; Guy M Bormans; Alfons M Verbruggen |
Publication Detail:
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Type: In Vitro; Journal Article Date: 2005-11-03 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 16 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-11-25 Completed Date: 2006-03-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 382-6 Citation Subset: IM |
Affiliation:
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Laboratory of Radiopharmaceutical Chemistry, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects, metabolism Drug Evaluation, Preclinical Isotope Labeling Mice Molecular Conformation Organotechnetium Compounds / chemistry* Structure-Activity Relationship Tissue Distribution Tropanes / chemical synthesis*, chemistry, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Organotechnetium Compounds; 0/Tropanes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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