| Synthesis and biological evaluation of receptor-based tumor imaging agent: (99m)Tc-folate-glucaric acid. | |
| | |
MedLine Citation:
|
PMID: 21782912 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The aim of the present study was to prepare (99m)Tc-folate-glucaric acid and investigate the radiopharmaceutical potential for tumors imaging that over express folate receptor. Folate-glucaric acid was synthesized and the synthesized folate conjugate was confirmed with (1)H NMR and LC-MS/MS methods. Folate-glucaric acid was labeled with (99m)Tc, and its radiolabelling efficiency was found as 96±2.0%. Biodistribution study of (99m)Tc-folate-glucaric acid was carried out in vivo using two groups of female Albino Wistar rats: folate receptor (FR) saturated and unsaturated. Biodistribution study showed that (99m)Tc-folate-glucaric acid indicated high uptake in folate receptor rich tissues such as breast, ovary and uterus. Therefore, (99m)Tc-folate-glucaric acid shows good radiolabeling and biodistribution in FR organs, the radiolabeled conjugate is a reason potentially useful radiopharmaceutical for detection of FR-positive tumors. |
| | |
Authors:
|
Mehmet Onursal; Fatma Yurt Lambrecht; Aykut Ozgur |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-18 |
Journal Detail:
|
Title: International journal of pharmaceutics Volume: - ISSN: 1873-3476 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
|
Department of Nuclear Applications, Institute of Nuclear Science, Ege University, Bornova 35100 Izmir, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of HPMC based polymers performance as carriers for manufacture of solid dispersions using...
Next Document: Sustained release of 5-fluorouracil by incorporation into sodium carboxymethylcellulose sub-micron f...