Document Detail

Synthesis and biological evaluation of fatty acids conjugates bearing cyclopentadienyl-donors incorporated [(99m)Tc/Re(CO)3](+) for myocardical imaging.
MedLine Citation:
PMID:  24333610     Owner:  NLM     Status:  Publisher    
Four (99m)Tc-labeled fatty acid analogs, 1b, 2b, 3b, 4b were synthesized by a double ligand transfer reaction and theirs potential were investigated. The radiochemical yield of the radiotracers was from 11.7% to 30.3% (no decay corrected). Those compounds were found to be chemically stable when incubated in SD rat serum for 3 h at 37 °C. The biodistribution studies in mice showed that high radioactivity accumulated of Tc-99m complexes were observed, followed by moderate clearance from the heart. The maximum heart/blood ratio was 5.7 at 15 min postinjection of 1b. Metabolite analysis showed 1b was not metabolized by β-oxidation in the heart. These results suggest that 1b may be a promising radiotracer for evaluation of myocardial viability.
Huahui Zeng; Huabei Zhang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-22
Journal Detail:
Title:  European journal of medicinal chemistry     Volume:  72C     ISSN:  1768-3254     ISO Abbreviation:  Eur J Med Chem     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0420510     Medline TA:  Eur J Med Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  10-17     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Masson SAS. All rights reserved.
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