Document Detail


Synthesis and biological evaluation of dehydroabietic acid derivatives.
MedLine Citation:
PMID:  19892441     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of C18-oxygenated derivatives of dehydroabietic acid were synthesized from commercial abietic acid and evaluated for their cytotoxic, antimycotic, and antiviral activities.
Authors:
Miguel A Gonz?lez; David P?rez-Guaita; Julieth Correa-Royero; Bibiana Zapata; Lee Agudelo; Ana Mesa-Arango; Liliana Betancur-Galvis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-13
Journal Detail:
Title:  European journal of medicinal chemistry     Volume:  45     ISSN:  1768-3254     ISO Abbreviation:  Eur J Med Chem     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0420510     Medline TA:  Eur J Med Chem     Country:  France    
Other Details:
Languages:  eng     Pagination:  811-6     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Masson SAS. All rights reserved.
Affiliation:
Departamento de Qu?mica Org?nica, Universidad de Valencia, E-46100 Burjassot, Valencia, Spain. miguel.a.gonzalez@uv.es
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MeSH Terms
Descriptor/Qualifier:
Animals
Antifungal Agents / chemical synthesis,  chemistry,  pharmacology
Antineoplastic Agents / chemical synthesis,  chemistry,  pharmacology
Antiviral Agents / chemical synthesis,  chemistry,  pharmacology
Cell Line, Tumor
Diterpenes, Abietane / chemical synthesis,  chemistry*,  pharmacology*
Fungi / drug effects
Herpesvirus 1, Human / drug effects
Humans
Hydrophobicity
Inhibitory Concentration 50
Microbial Sensitivity Tests
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Antineoplastic Agents; 0/Antiviral Agents; 0/Diterpenes, Abietane; 1740-19-8/dehydroabietic acid; 514-10-3/abietic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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