Document Detail


Synthesis and biological evaluation of a cyclic ether fluorinated noscapine analog.
MedLine Citation:
PMID:  17008104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present here a novel semi-synthetic cyclic ether fluorinated noscapine analog (CEFNA) that shows potent antiproliferative and anticancer activity in both hormone-responsive (MCF-7) and hormone non-responsive (MDA-MB-231) breast cancer cells. Interestingly, it is also effective against MCF-7/Adr, an adriamycin-resistant variant of MCF-7 cells. Immunofluorescence experiments showed numerous micronuclei, indicative of apoptotic cell death triggered by this novel analog. Mechanistically, CEFNA exerts a strong antimitotic effect as revealed by cell-cycle studies that show a dose-dependent increase in G2/M population preceding a rising sub-G1 population, suggesting apoptosis.
Authors:
Ritu Aneja; Surya N Vangapandu; Harish C Joshi
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural     Date:  2006-09-27
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  14     ISSN:  0968-0896     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-07     Completed Date:  2007-02-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  8352-8     Citation Subset:  IM    
Affiliation:
Laboratory for Drug Discovery and Research, Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA. raneja@emory.edu
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MeSH Terms
Descriptor/Qualifier:
Antibiotics, Antineoplastic / adverse effects
Antitussive Agents / chemical synthesis*,  chemistry,  pharmacology*
Apoptosis / drug effects
Breast Neoplasms / drug therapy,  pathology
Cell Cycle / drug effects
Doxorubicin / adverse effects
Drug Resistance, Neoplasm
Flow Cytometry
Fluorescent Antibody Technique
Humans
Mitotic Spindle Apparatus / drug effects
Noscapine / chemical synthesis*,  chemistry,  pharmacology*
Tumor Cells, Cultured / drug effects
Grant Support
ID/Acronym/Agency:
R01 CA095317-01A2/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Antitussive Agents; 128-62-1/Noscapine; 23214-92-8/Doxorubicin

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