Document Detail


Synthesis and biological evaluation of O-methyl and O-ethyl NSAID hydroxamic acids.
MedLine Citation:
PMID:  19772490     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
This paper reports the synthesis of O-methyl and O-ethyl NSAID hydroxamic acids, their antimicrobial activities, and their ability to inhibit urease and soybean lipoxygenase activities. Ibuprofen and fenoprofen hydroxamic acids with free hydroxy groups present the highest antimicrobial activity, while indomethacin and diclofenac analogs show significantly lower antimicrobial activity. Diclofenac hydroxamic acid 4e exerts the highest anti-urease activity. Indomethacin O-ethyl hydroxamic acid 3h and ibuprofen O-benzyl hydroxamic acid 4b exert significant inhibitory activities on soybean lipoxygenase. Fenoprofen and indomethacin O-ethyl hydroxamic acids 3b and 3h and diclofenac and indomethacin O-benzyl analogs 4g and 4i highly inhibit lipid peroxidation. The highest antioxidant activity was shown by fenoprofen derivative 3b.
Authors:
Zrinka Rajić; Ivana Perković; Ivan Butula; Branka Zorc; Dimitra Hadjipavlou-Litina; Eleni Pontiki; Stjepan Pepeljnjak; Ivan Kosalec
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of enzyme inhibition and medicinal chemistry     Volume:  24     ISSN:  1475-6374     ISO Abbreviation:  J Enzyme Inhib Med Chem     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101150203     Medline TA:  J Enzyme Inhib Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  1179-87     Citation Subset:  IM    
Affiliation:
Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
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