| Synthesis and biological evaluation of N-substituted indole esters as inhibitors of cyclo-oxygenase-2 (COX-2). | |
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MedLine Citation:
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PMID: 12361236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of novel N-substituted indole carboxylic, acetic and propionic acid esters have been prepared as possible cyclo-oxygenase-2 (COX-2) enzyme inhibitors. Compounds 20, 23 were found slightly active against COX-2. The synthesis of indole carboxylic, acetic and propionic acid esters were furnished by using dicyclohexyl carbodiimide (DCC), dimethylamino pyridine (DMAP) as carboxylate activators. N-substitution of indole esters was verified with several benzyl and benzoyl group in presence of NaH in DMF, respectively. |
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Authors:
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Süreyya Olgen; Doğu Nebioglu |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Farmaco (Società chimica italiana : 1989) Volume: 57 ISSN: 0014-827X ISO Abbreviation: Farmaco Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-10-03 Completed Date: 2003-03-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8912641 Medline TA: Farmaco Country: Italy |
Other Details:
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Languages: eng Pagination: 677-83 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Catania, Italy. olgen@pharmacy.ankara.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors / chemical synthesis*, chemistry, pharmacology* Drug Evaluation, Preclinical / methods Esters / chemical synthesis, chemistry, pharmacology Indoles / chemical synthesis*, chemistry, pharmacology* Isoenzymes / antagonists & inhibitors*, metabolism Prostaglandin-Endoperoxide Synthases / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cyclooxygenase 2 Inhibitors; 0/Cyclooxygenase Inhibitors; 0/Esters; 0/Indoles; 0/Isoenzymes; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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