Document Detail


Synthesis and biological evaluation of N-substituted indole esters as inhibitors of cyclo-oxygenase-2 (COX-2).
MedLine Citation:
PMID:  12361236     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of novel N-substituted indole carboxylic, acetic and propionic acid esters have been prepared as possible cyclo-oxygenase-2 (COX-2) enzyme inhibitors. Compounds 20, 23 were found slightly active against COX-2. The synthesis of indole carboxylic, acetic and propionic acid esters were furnished by using dicyclohexyl carbodiimide (DCC), dimethylamino pyridine (DMAP) as carboxylate activators. N-substitution of indole esters was verified with several benzyl and benzoyl group in presence of NaH in DMF, respectively.
Authors:
Süreyya Olgen; Doğu Nebioglu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Farmaco (Società chimica italiana : 1989)     Volume:  57     ISSN:  0014-827X     ISO Abbreviation:  Farmaco     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-10-03     Completed Date:  2003-03-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912641     Medline TA:  Farmaco     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  677-83     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Catania, Italy. olgen@pharmacy.ankara.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors / chemical synthesis*,  chemistry,  pharmacology*
Drug Evaluation, Preclinical / methods
Esters / chemical synthesis,  chemistry,  pharmacology
Indoles / chemical synthesis*,  chemistry,  pharmacology*
Isoenzymes / antagonists & inhibitors*,  metabolism
Prostaglandin-Endoperoxide Synthases / metabolism
Chemical
Reg. No./Substance:
0/Cyclooxygenase 2 Inhibitors; 0/Cyclooxygenase Inhibitors; 0/Esters; 0/Indoles; 0/Isoenzymes; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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