Document Detail


Synthesis and biological aspects of mycolic acids: an important target against Mycobacterium tuberculosis.
MedLine Citation:
PMID:  18677428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mycolic acids are an important class of compounds, basically found in the cell walls of a group of bacteria known as mycolata taxon, exemplified by the most famous bacteria of this group, the Mycobacterium tuberculosis (M. tb.), the agent responsible for the disease known as tuberculosis (TB). Mycolic acids are important for the survival of M. tb. For example, they are able to help fight against hydrophobic drugs and dehydration, and also allow this bacterium to be more effective in the host's immune system by growing inside macrophages. Due to the importance of the mycolic acids for maintenance of the integrity of the mycobacterial cell wall, these compounds become attractive cellular targets for the development of novel drugs against TB. In this context, the aim of this article is to highlight the importance of mycolic acids in drug discovery.
Authors:
Marcus Vinícius Nora de Souza; Marcelle de Lima Ferreira; Alessandra Campbell Pinheiro; Maurício Frota Saraiva; Mauro Vieira de Almeida; Marcelo Siqueira Valle
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-07-31
Journal Detail:
Title:  TheScientificWorldJournal     Volume:  8     ISSN:  1537-744X     ISO Abbreviation:  ScientificWorldJournal     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-04     Completed Date:  2008-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101131163     Medline TA:  ScientificWorldJournal     Country:  England    
Other Details:
Languages:  eng     Pagination:  720-51     Citation Subset:  IM    
Affiliation:
Instituto de Tecnologia em Fármacos-Far-Manguinhos, Rua Sizenando Nabuco,100, Manguinhos, 21041-250 Rio de Janeiro, RJ - Brazil. marcos_souza@far.fiocruz.br
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MeSH Terms
Descriptor/Qualifier:
Antitubercular Agents / pharmacology*
Drug Design
Mycobacterium tuberculosis / drug effects*,  metabolism
Mycolic Acids / metabolism*
Chemical
Reg. No./Substance:
0/Antitubercular Agents; 0/Mycolic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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