Document Detail

Synthesis, biological activity of salidroside and its analogues.
MedLine Citation:
PMID:  21139267     Owner:  NLM     Status:  MEDLINE    
Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, about 18 novel salidroside analogues were prepared through Koenigs-Knorr method, the effects of these compounds over PC12 was assessed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The novel compounds differ in the substituents attached to the benzene ring or in the glycosyl donor. According to the data, compounds (3,5-dimethoxyphenyl)methyl β-D-glucopyranoside and (3,5-dimethoxyphenyl)methyl β-D-galactopyranoside with methoxy group at 3 and 5-positions of the benzene ring were the most viability at concentration of 300 µmol/l and 60 µmol/l, respectively.
Yibing Guo; Yahong Zhao; Cheng Zheng; Ying Meng; Yumin Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  58     ISSN:  1347-5223     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-08     Completed Date:  2011-03-24     Revised Date:  2012-10-09    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1627-9     Citation Subset:  IM    
Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, China.
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MeSH Terms
Cell Line, Tumor
Cell Survival
Glucosides / chemical synthesis,  chemistry*,  toxicity
Phenols / chemical synthesis,  chemistry*,  toxicity
Plants, Medicinal / chemistry
Rhodiola / chemistry
Reg. No./Substance:
0/Glucosides; 0/Phenols; 10338-51-9/rhodioloside

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