| Synthesis, biological activity of salidroside and its analogues. | |
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MedLine Citation:
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PMID: 21139267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Salidroside is a phenylpropanoid glycoside isolated from Rhodiola rosea L., a traditional Chinese medicinal plant, and has displayed a broad spectrum of pharmacological properties. In this paper, about 18 novel salidroside analogues were prepared through Koenigs-Knorr method, the effects of these compounds over PC12 was assessed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The novel compounds differ in the substituents attached to the benzene ring or in the glycosyl donor. According to the data, compounds (3,5-dimethoxyphenyl)methyl β-D-glucopyranoside and (3,5-dimethoxyphenyl)methyl β-D-galactopyranoside with methoxy group at 3 and 5-positions of the benzene ring were the most viability at concentration of 300 µmol/l and 60 µmol/l, respectively. |
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Authors:
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Yibing Guo; Yahong Zhao; Cheng Zheng; Ying Meng; Yumin Yang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 58 ISSN: 1347-5223 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-08 Completed Date: 2011-03-24 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 1627-9 Citation Subset: IM |
Affiliation:
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Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line, Tumor Cell Survival Glucosides / chemical synthesis, chemistry*, toxicity Phenols / chemical synthesis, chemistry*, toxicity Plants, Medicinal / chemistry Rats Rhodiola / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Glucosides; 0/Phenols; 10338-51-9/rhodioloside |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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