Document Detail


Synthesis and biological activity of 125I/127I-phenylboronic acid derivatives.
MedLine Citation:
PMID:  8166883     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three iodinated phenylboronic acids have been synthesized: 4-iodophenylboronic acid (2a), 3-(4-iodobenzenesulfonamido)phenylboronic acid (5a) and 3-(5-dimethylamino-6-iodo-1-naphthalenesulfonamido)phenylboronic acid (6a). The corresponding no-carrier-added 125I derivatives 2b, 5b and 6b have been prepared in good yield by selective displacement of the tributylstannyl group. Compound 6b was concentrated in vitro preferentially in HT-29 human colon carcinoma cells compared to V79 Chinese hamster lung fibroblasts and showed selective retention in PaCa-2 human pancreatic cancer cells grown as solid tumor xenografts in the nude mouse.
Authors:
B M Kinsey; A I Kassis
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nuclear medicine and biology     Volume:  20     ISSN:  0969-8051     ISO Abbreviation:  Nucl. Med. Biol.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-04-30     Completed Date:  1993-04-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9304420     Medline TA:  Nucl Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  13-22     Citation Subset:  IM    
Affiliation:
Department of Radiology, Harvard Medical School, Shields Warren Radiation Laboratory, Boston, MA 02115.
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MeSH Terms
Descriptor/Qualifier:
Animals
Boron Compounds / chemical synthesis*,  pharmacokinetics,  pharmacology
Cells, Cultured
Cricetinae
Cricetulus
Humans
Iodine Radioisotopes
Iodobenzenes / chemical synthesis*,  pharmacokinetics,  pharmacology
Mice
Mice, Nude
Neoplasm Transplantation
Neoplasms, Experimental / etiology,  metabolism
Sulfonamides / chemical synthesis*,  pharmacokinetics,  pharmacology
Tissue Distribution
Tumor Cells, Cultured
Grant Support
ID/Acronym/Agency:
5T32 CA 09536-01/CA/NCI NIH HHS; R01 CA 15523-14/CA/NCI NIH HHS; RR 00317/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Boron Compounds; 0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Sulfonamides; 147353-48-8/3-(4-iodobenzenesulfonamido)phenylboronic acid; 147353-58-0/3-(5-dimethylamino-6-iodo-1-naphthalenesulfonamido)phenylboronic acid; 5122-99-6/4-iodophenylboronic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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