Document Detail


Synthesis and biological activity of a novel series of 4-[2'-(6'-nitro)benzimidazolyl]benzoyl amino acids and peptides.
MedLine Citation:
PMID:  14971314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of new 4-[2'-(6'-nitro)benzimidazolyl]benzoyl amino acids and peptides have been synthesized by coupling the 4-[2'-(6'-nitro)benzimidazolyl]benzoic acid with amino acid methyl esters/dipeptides using DCC as the coupling agent. All the synthesized compounds were found to exhibit potent anthelmintic activity along with moderate antimicrobial activity.
Authors:
M Himaja; Rajiv; M V Ramana; Boja Poojary; D Satyanarayana; E V Subrahmanyam; K Ishwar Bhat
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bollettino chimico farmaceutico     Volume:  142     ISSN:  0006-6648     ISO Abbreviation:  Boll Chim Farm     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-02-19     Completed Date:  2004-03-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372534     Medline TA:  Boll Chim Farm     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  450-3     Citation Subset:  IM    
Affiliation:
NGSM Institute of Pharmaceutical Sciences, Nanthoor, Mangalore, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthelmintics / chemical synthesis*,  pharmacology*
Anti-Infective Agents / chemical synthesis*,  pharmacology*
Bacteria / drug effects
Benzoates / chemical synthesis*,  pharmacology*
Helminths
Imidazoles / chemical synthesis*,  pharmacology*
Indicators and Reagents
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbial Sensitivity Tests
Peptides / chemical synthesis*,  pharmacology*
Spectrophotometry, Infrared
Chemical
Reg. No./Substance:
0/Anthelmintics; 0/Anti-Infective Agents; 0/Benzoates; 0/Imidazoles; 0/Indicators and Reagents; 0/Peptides

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