| Synthesis and biological activity of the intercalating agent 3-acetamido-5-[123/125I]iodo-6-aminoacridine. | |
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MedLine Citation:
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PMID: 2341291 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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3-Acetamido-5-iodo-6-aminoacridine (3), a derivative of the known intercalating agent proflavine (3,6-diaminoacridine) (1) was synthesized, and no-carrier-added 123I and 125I labeled compounds prepared. Compound 3 was taken up by live cells and localized in the nucleus. The intracellular concentration of [125I]3 was 7-fold greater in human prostate carcinoma (PC-3) cells than in normal Chinese hamster lung fibroblast (V-79) cells. |
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Authors:
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B M Kinsey; F Fayad; C N Venkateshan; S J Adelstein; A I Kassis |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Volume: 17 ISSN: 0883-2897 ISO Abbreviation: Int J Rad Appl Instrum B Publication Date: 1990 |
Date Detail:
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Created Date: 1990-06-26 Completed Date: 1990-06-26 Revised Date: 2008-02-21 |
Medline Journal Info:
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Nlm Unique ID: 8611098 Medline TA: Int J Rad Appl Instrum B Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 341-6 Citation Subset: IM |
Affiliation:
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Department of Radiology (Nuclear Medicine), Harvard Medical School, Boston, MA 02115. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acridines
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chemical synthesis* DNA / metabolism Humans Intercalating Agents / chemical synthesis*, metabolism, pharmacokinetics Iodine Radioisotopes / therapeutic use Isotope Labeling Male Proflavine / analogs & derivatives, chemical synthesis*, metabolism, pharmacokinetics Prostatic Neoplasms / metabolism, radiotherapy |
| Grant Support | |
ID/Acronym/Agency:
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5T32 CA 09536-01/CA/NCI NIH HHS; R01 CA 15523-14/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acridines; 0/Intercalating Agents; 0/Iodine Radioisotopes; 121284-42-2/3-acetamido-5-iodoproflavine; 9007-49-2/DNA; 92-62-6/Proflavine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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