Document Detail

Synthesis, biological activity and conformational studies of geometrically restricted tripeptide analogues of the chemoattractant HCO-Met-Leu-Phe-OMe.
MedLine Citation:
PMID:  9372595     Owner:  NLM     Status:  MEDLINE    
The formyl tripeptides containing 2-azetidinecarboxylic acid 2, 2-piperidinecarboxylic acid 3 and norvaline 4 in position 2 were synthesized and their biological activity was evaluated. The conformation of peptides was studied by CD and FT-IR techniques. While 2 and 3 do not show either chemotactic activity or superoxide production, 4 retains both activities.
M Boggian; G Vertuani; G Cavicchioni; R Pecoraro; A Scatturin; S Spisani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Farmaco (Società chimica italiana : 1989)     Volume:  52     ISSN:  0014-827X     ISO Abbreviation:  Farmaco     Publication Date:    1997 Jun-Jul
Date Detail:
Created Date:  1998-02-27     Completed Date:  1998-02-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912641     Medline TA:  Farmaco     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  439-44     Citation Subset:  IM    
Dipartimento di Scienze Farmaceutiche, Università di Ferrara.
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MeSH Terms
Cell Movement
Chemotactic Factors / chemistry*,  pharmacology
N-Formylmethionine Leucyl-Phenylalanine / analogs & derivatives*,  chemistry,  pharmacology
Neutrophils / drug effects*,  metabolism,  physiology
Oligopeptides / chemistry*,  pharmacology
Protein Conformation
Superoxides / metabolism
Reg. No./Substance:
0/Chemotactic Factors; 0/Oligopeptides; 0/Solutions; 11062-77-4/Superoxides; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine; 65929-03-5/formylmethionyl-leucyl-phenylalanine methyl ester

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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