Document Detail


Synthesis and biological activity of 10-thia-10-deaza analogs of folic acid, pteroic acid, and related compounds.
MedLine Citation:
PMID:  808608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The 10-thia analogs of pteroic acid, folic acid, their esters, and their 4-amino analogs were synthesized through a reaction sequence involving, as a key step, the condensation of 2-amino-3-cyano-5-chloromethylpyrazine with appropriately substituted thiols. The abilities of the products to inhibit the growth of methotrexate (MTX)-sensitive and MTX-resistant microorganisms were investigated as were their abilities to inhibit dihydrofolic acid reductase and thymidylic acid synthetase. Several compounds had high activity.
Authors:
Y H Kim; Y Gaumont; R L Kisliuk; H G Mautner
Related Documents :
2790798 - Folate and methotrexate interactions in the rat kidney.
16898 - Identification of folate binding macromolecule in rabbit choroid plexus.
17212668 - Folic acid prevents neural tube defects: international comparison of awareness among ob...
9489188 - Promotion of folate for the prevention of neural tube defects: knowledge and use of per...
5086658 - Changes in free amino acid production and intracellular amino acid pools of bacillus li...
18433808 - Anti-hiv-1 protease triterpenoids from stauntonia obovatifoliola hayata subsp. intermedia.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  18     ISSN:  0022-2623     ISO Abbreviation:  J. Med. Chem.     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1975-11-22     Completed Date:  1975-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  776-80     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Enterococcus faecalis / drug effects
Folic Acid / analogs & derivatives*,  chemical synthesis,  pharmacology
Folic Acid Antagonists
Lactobacillus casei / drug effects,  enzymology
Magnetic Resonance Spectroscopy
Pterins / chemical synthesis*,  pharmacology
Thymidylate Synthase / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Folic Acid Antagonists; 0/Pterins; 59-30-3/Folic Acid; EC 2.1.1.45/Thymidylate Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Chemistry of cephalosporin antibiotics. 28. Preparation and biological activity of 3-(substituted)vi...
Next Document:  Synthesis and biological activity of 5-fluoro-4'-thiouridine and some related nucleosides.