Document Detail

Synthesis and biological activity of 10-thia-10-deaza analogs of folic acid, pteroic acid, and related compounds.
MedLine Citation:
PMID:  808608     Owner:  NLM     Status:  MEDLINE    
The 10-thia analogs of pteroic acid, folic acid, their esters, and their 4-amino analogs were synthesized through a reaction sequence involving, as a key step, the condensation of 2-amino-3-cyano-5-chloromethylpyrazine with appropriately substituted thiols. The abilities of the products to inhibit the growth of methotrexate (MTX)-sensitive and MTX-resistant microorganisms were investigated as were their abilities to inhibit dihydrofolic acid reductase and thymidylic acid synthetase. Several compounds had high activity.
Y H Kim; Y Gaumont; R L Kisliuk; H G Mautner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  18     ISSN:  0022-2623     ISO Abbreviation:  J. Med. Chem.     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1975-11-22     Completed Date:  1975-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  776-80     Citation Subset:  IM    
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MeSH Terms
Enterococcus faecalis / drug effects
Folic Acid / analogs & derivatives*,  chemical synthesis,  pharmacology
Folic Acid Antagonists
Lactobacillus casei / drug effects,  enzymology
Magnetic Resonance Spectroscopy
Pterins / chemical synthesis*,  pharmacology
Thymidylate Synthase / antagonists & inhibitors
Reg. No./Substance:
0/Folic Acid Antagonists; 0/Pterins; 59-30-3/Folic Acid; EC Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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