| Synthesis and biological activities of diquaternary dipiperazinium salts containing dithiocarboxyl groups. | |
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MedLine Citation:
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PMID: 11413824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of diquaternary dipiperazinium salts containing dithiocarboxyl groups 6a-f and 9 were synthesized and evaluated for their analgesic and sedative activities. The result showed that the presence of two quaternary ammonium cations and the distance between them are very important for the activities of the salts. Compound 6b exhibited the best activities (at dose 2 mg/kg, analgesic, 57%; sedative, 59%) among compounds 6a-f. Compound 9 not only showed the most potent analgesic (85.4%, dose 1 mg/kg) and sedative (93.1%, dose 1 mg/kg) activities, but also exhibited anticancer activity against KB (68.7%, dose 10 microM). |
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Authors:
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Z M Ge; R T Li; T M Cheng; J R Cui |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archiv der Pharmazie Volume: 334 ISSN: 0365-6233 ISO Abbreviation: Arch. Pharm. (Weinheim) Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-06-20 Completed Date: 2001-08-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0330167 Medline TA: Arch Pharm (Weinheim) Country: Germany |
Other Details:
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Languages: eng Pagination: 173-6 Citation Subset: IM |
Affiliation:
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School of Pharmaceutical Sciences, Peking University, Beijing, 100083, P.R. China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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chemical synthesis*,
pharmacology Animals Antineoplastic Agents / chemical synthesis, pharmacology Cell Division / drug effects Dimerization Drug Evaluation, Preclinical Female Humans Hypnotics and Sedatives / chemical synthesis*, pharmacology KB Cells / drug effects Male Mice Piperazines / chemical synthesis, pharmacology Quaternary Ammonium Compounds / chemical synthesis, pharmacology Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Antineoplastic Agents; 0/Hypnotics and Sedatives; 0/Piperazines; 0/Quaternary Ammonium Compounds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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