| Synthesis of artificial lymphoid tissue with immunological function. | |
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MedLine Citation:
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PMID: 20951645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability to generate functional artificial lymphoid tissue to induce specific immunity at ectopic sites could offer a potential breakthrough for treatment of diseases such as cancer and severe infection using immunotherapy. Artificial lymphoid tissue could also offer an informative tool to study further lymphoid tissue development and function in vivo. Here, we review the process of secondary and tertiary lymphoid organization, of which an understanding is essential for artificial lymphoid tissue synthesis. Using this knowledge, we consider the combination of cell types, soluble factors and scaffold properties that will enable proper accumulation and organization of lymphocytes into tissue grafts. Recent success in in vivo induction of artificial lymphoid tissue are also considered. |
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Authors:
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Yuka Kobayashi; Takeshi Watanabe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-10-15 |
Journal Detail:
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Title: Trends in immunology Volume: 31 ISSN: 1471-4981 ISO Abbreviation: Trends Immunol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966032 Medline TA: Trends Immunol Country: England |
Other Details:
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Languages: eng Pagination: 422-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Graduate School of Medicine, Kyoto University, Yoshida-konoe machi, Sakyo-ku, Kyoto 606-8501, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptive Immunity Animals Artificial Organs Chemokines / immunology Humans Lymphocytes / immunology Lymphoid Tissue / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Chemokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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