Document Detail


Synthesis of arachidonic acid in the human placenta in vitro.
MedLine Citation:
PMID:  435597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The syntheses of arachidonic acid and total fatty acids were measured in human placentas at the end of the first trimester and at term using 14C-acetate in in vitro incorporation experiments. The rates of arachidonic acid synthesis were determined to be 0.70 (first trimester) and 0.64 (term) mumol/h/100 g of placental tissue. The calculated rates of total fatty acid synthesis amount to 0.5 (first trimester) and 0.6 (term) mumol palmitate-equivalents/h/100 g. The results suggest that the human placenta seems to be not dependent on maternal arachidonic acid. Near term the placenta even could be source of arachidonic acid.
Authors:
T Zimmermann; L Winkler; U Möller; H Schubert; E Goetze
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  35     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1979  
Date Detail:
Created Date:  1979-07-16     Completed Date:  1979-07-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  209-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Arachidonic Acids / biosynthesis*
Fatty Acids / biosynthesis
Female
Humans
Placenta / metabolism*
Pregnancy
Pregnancy Trimester, First
Pregnancy Trimester, Third
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Fatty Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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