| Synthesis and application of a novel single-isomer mono-6-deoxy-6-((2S,3S)-(+)-2,3-O-isopropylidene-1,4-tetramethylenediamine)-β-cyclodextrin as chiral selector in capillary electrophoresis. | |
| | |
MedLine Citation:
|
PMID: 20872667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A novel single isomer of positively charged β-cyclodextrin, mono-6-deoxy-6-((2S,3S)-(+)-2,3-O-isopropylidene-1,4-tetramethylenediamine)-β-CD (MIPTACD) was designed and synthesized in seven steps starting from commercially available (2R,3R)-tartaric acid. The chiral resolution abilities of the new cationic chiral selector were studied by capillary electrophoresis using 10 different dansyl (Dns)-amino acids and N-acetylphenylalanine (N-Ac-Phe) as model analytes. The effects of running buffer pH and chiral selector concentration on the separation selectivity, resolutions, and migration times of analytes were studied in detail. MIPTACD shows a very good chiral recognition ability even at very low concentrations at the investigated pH values, as shown by the very large values of selectivity and resolution towards amino acids enantiomers to be assessed. |
| | |
Authors:
|
Peng Liu; Wei He; Xiang-Yang Qin; Xiao-Li Sun; Hui Chen; Sheng-Yong Zhang |
Related Documents
:
|
17719197 - Comparative study of immobilized alpha 1 acid glycoprotein and ovomucoid protein statio... 17357177 - Simultaneous determination of phenylglyoxylic acid, mandelic acid, styrene glycol and h... 11001287 - New aspects of buffering with multivalent weak acids in capillary zone electrophoresis:... 8318837 - Sensitive determination of enantiomers of amino acids derivatized with the fluorogenic ... 17164127 - Erythrocyte-derived epoxyeicosatrienoic acids. 2789317 - Interleukin 1 and tumor necrosis factor: studies on the induction by lipopolysaccharide... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Chirality Volume: 22 ISSN: 1520-636X ISO Abbreviation: Chirality Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-09-27 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8914261 Medline TA: Chirality Country: United States |
Other Details:
|
Languages: eng Pagination: 914-21 Citation Subset: IM |
Copyright Information:
|
© 2010 Wiley-Liss, Inc. |
Affiliation:
|
Department of Chemistry, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acids
/
chemistry,
isolation & purification Buffers Dansyl Compounds / chemistry Dioxoles / chemical synthesis*, chemistry* Electrophoresis, Capillary / methods* Hydrogen-Ion Concentration Indicators and Reagents Isomerism Molecular Conformation Solutions Stereoisomerism beta-Cyclodextrins / chemical synthesis, chemistry* |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids; 0/Buffers; 0/Dansyl Compounds; 0/Dioxoles; 0/Indicators and Reagents; 0/Solutions; 0/beta-Cyclodextrins; 0/mono-6-deoxy-6-(2,3-O-isopropylidene-1,4-tetramethylenediamine)-beta-cyclodextrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Open system approaches in deterministic models of the emergence of homochirality.
Next Document: Supercritical fluid chromatography and steady-state recycling: phase appropriate technologies for th...