| Synthesis and application of negatively charged PNA analogues. | |
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MedLine Citation:
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PMID: 16438053 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Negatively charged DNA mimics containing phosphonate analogoues of peptide nucleic acids were designed, and their physicochemical and biological properties were evaluated in the comparison with natural oligonucleotides, classical peptide nucleic acids, and morpholino phosphorodiamidate oligonucleotide analogues. The results obtained revealed a high potential of phosphonate-containing PNA derivatives for a number of biological applications, such as diagnostic, nucleic acids analysis, and inhibition of gene expression. |
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Authors:
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Vladimir A Efimov; Oksana G Chakhmakhcheva; Eric Wickstrom |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nucleosides, nucleotides & nucleic acids Volume: 24 ISSN: 1525-7770 ISO Abbreviation: Nucleosides Nucleotides Nucleic Acids Publication Date: 2005 |
Date Detail:
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Created Date: 2006-01-27 Completed Date: 2006-03-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100892832 Medline TA: Nucleosides Nucleotides Nucleic Acids Country: United States |
Other Details:
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Languages: eng Pagination: 1853-74 Citation Subset: IM |
Affiliation:
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Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia. eva@mail.ibch.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Escherichia coli / genetics Gene Targeting / methods Oligonucleotides / chemical synthesis, chemistry, pharmacology Peptide Nucleic Acids / chemical synthesis*, genetics, pharmacology RNA Interference / drug effects Zebrafish / embryology, genetics |
| Chemical | |
Reg. No./Substance:
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0/Oligonucleotides; 0/Peptide Nucleic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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