Document Detail


Synthesis and antiviral activities of some 4,4'-dihydroxytriphenylmethanes.
MedLine Citation:
PMID:  14600384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
4,4'-Dihydroxytriphenylmethanes were synthesized using Brønsted acid or Lewis acid in yields of 24-86% as target compounds for developing antiviral agents. Most of the 4,4'-dihydroxytriphenylmethanes showed significant activity against herpes simplex virus type 1 (anti-HSV-1 activity) in a plaque reduction assay. Higher cytotoxicity was observed generally in halogenated 4,4'-dihydroxytriphenylmethanes (2a-d) than in non-halogenated derivatives. The non-halogenated derivative, 4,4',4"-trihydroxy-3"-methoxytriphenylmethane (3), showed remarkable antiviral activity with an EC(50) value of 1.8 microg/ml.
Authors:
Nobuko Mibu; Kazumi Yokomizo; Masaru Uyeda; Kunihiro Sumoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  51     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-05     Completed Date:  2004-06-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1325-7     Citation Subset:  IM    
Affiliation:
Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan-ku, Fukuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Alkanes / chemical synthesis*,  pharmacology*
Antiviral Agents / chemical synthesis*,  pharmacology*
Cell Survival / drug effects
Chemistry, Physical
Herpesvirus 1, Human / drug effects
Magnetic Resonance Spectroscopy
Mass Spectrometry
Physicochemical Phenomena
Plaque Assay
Polycyclic Hydrocarbons, Aromatic / chemical synthesis*,  pharmacology*
Spectrophotometry, Infrared
Chemical
Reg. No./Substance:
0/Alkanes; 0/Antiviral Agents; 0/Polycyclic Hydrocarbons, Aromatic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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