Document Detail

Synthesis and antiviral activities of some 4,4'-dihydroxytriphenylmethanes.
MedLine Citation:
PMID:  14600384     Owner:  NLM     Status:  MEDLINE    
4,4'-Dihydroxytriphenylmethanes were synthesized using Brønsted acid or Lewis acid in yields of 24-86% as target compounds for developing antiviral agents. Most of the 4,4'-dihydroxytriphenylmethanes showed significant activity against herpes simplex virus type 1 (anti-HSV-1 activity) in a plaque reduction assay. Higher cytotoxicity was observed generally in halogenated 4,4'-dihydroxytriphenylmethanes (2a-d) than in non-halogenated derivatives. The non-halogenated derivative, 4,4',4"-trihydroxy-3"-methoxytriphenylmethane (3), showed remarkable antiviral activity with an EC(50) value of 1.8 microg/ml.
Nobuko Mibu; Kazumi Yokomizo; Masaru Uyeda; Kunihiro Sumoto
Related Documents :
1838104 - Microbial de-mannosylation and mannosylation of teicoplanin derivatives.
3771124 - S.e.m. study of urease-induced crystalluria in the presence of hydroxamic derivatives.
11303954 - Development of novel lipophilic derivatives of dadle (leucine enkephalin analogue): int...
2727024 - Study of local anaesthetics. part 93: a contribution to the study of osar in the group ...
22314904 - Effect of intragastric administration of crude aqueous leaf extract of anacardium occid...
17539604 - Mass + retention time = structure: a strategy for the analysis of n-glycans by carbon l...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  51     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-05     Completed Date:  2004-06-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1325-7     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan-ku, Fukuoka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alkanes / chemical synthesis*,  pharmacology*
Antiviral Agents / chemical synthesis*,  pharmacology*
Cell Survival / drug effects
Chemistry, Physical
Herpesvirus 1, Human / drug effects
Magnetic Resonance Spectroscopy
Mass Spectrometry
Physicochemical Phenomena
Plaque Assay
Polycyclic Hydrocarbons, Aromatic / chemical synthesis*,  pharmacology*
Spectrophotometry, Infrared
Reg. No./Substance:
0/Alkanes; 0/Antiviral Agents; 0/Polycyclic Hydrocarbons, Aromatic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A new naphthopyrone from the root of Pleuropterus ciliinervis.
Next Document:  Prenylated xanthones from Garcinia xanthochymus.