Document Detail

Synthesis and antitumor activity of substituted triazolo[4,3-a]pyrimidin-6-sulfonamide with an incorporated thiazolidinone moiety.
MedLine Citation:
PMID:  19540114     Owner:  NLM     Status:  MEDLINE    
Chlorosulfonation of 3-methyl[1,2,4]triazolo[4,3-a]pyrimidine with chlorosulfonic acid in the presence of thionyl chloride was studied. When triazolo[4,3-a]pyrimidines are used as substrates, the substitution occurs at C-6. Also the reactivity of the hydrazides (7) towards aldehydes, thioglycolic acid and amines were studies. The newly prepared compounds 10a,d and 11a,d demonstrated inhibitory effects on the growth of a wide range of cancer cell lines generally at 10(-5)M level and in some cases at 10(-7)M concentrations.
Hend N Hafez; Abdel-Rahman B A El-Gazzar
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Publication Detail:
Type:  Journal Article     Date:  2009-06-06
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  19     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-14     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  4143-7     Citation Subset:  IM    
National Research Centre, Photochemistry Department (Heterocyclic & Nucleoside Unit), Dokki, 12622 Cairo, Egypt.
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MeSH Terms
Amides / chemistry
Antineoplastic Agents / chemical synthesis*,  pharmacology
Cell Line, Tumor
Cell Proliferation
Cell Survival
Drug Design
Drug Screening Assays, Antitumor
Models, Chemical
Pyrimidines / chemical synthesis*,  pharmacology
Structure-Activity Relationship
Sulfonamides / chemical synthesis*,  pharmacology
Sulfur Oxides / chemistry
Thiazoles / chemistry*
Reg. No./Substance:
0/Amides; 0/Antineoplastic Agents; 0/Pyrimidines; 0/Sulfonamides; 0/Sulfur Oxides; 0/Thiazoles; 7719-09-7/thionyl chloride

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