| Synthesis and antitumor activity of 2,5-bis(3'-indolyl)-furans and 3,5-bis(3'-indolyl)-isoxazoles, nortopsentin analogues. | |
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MedLine Citation:
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PMID: 20472437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of novel 2,5-bis(3'-indolyl)furans and 3,5-bis(3'-indolyl)isoxazoles were synthesized as antitumor agents. The antiproliferative activity was evaluated in vitro toward diverse human tumor cell lines. Initially 5 isoxazoles and 3 furan derivatives were tested against a panel of 10 human tumor cell lines and the most active derivatives 3c and 4a were selected to be evaluated in an extended panel of 29 cell lines. By exhibiting mean IC(50) values of 17.4 microg/mL (3a) and 20.5 microg/mL (4c), in particular 4c showed a high level of tumor selectivity toward the 29 cell lines. |
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Authors:
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Patrizia Diana; Anna Carbone; Paola Barraja; Gerhard Kelter; Heinz-Herbert Fiebig; Girolamo Cirrincione |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-28 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 18 ISSN: 1464-3391 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 4524-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Dipartimento Farmacochimico, Tossicologico e Biologico, Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
/
chemical synthesis*,
chemistry,
therapeutic use Cell Line, Tumor Drug Screening Assays, Antitumor Furans / chemical synthesis, chemistry*, therapeutic use Humans Indoles / chemical synthesis, chemistry*, therapeutic use Isoxazoles / chemical synthesis, chemistry*, therapeutic use Neoplasms / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/3-3'-furan-2,5-diylbis(1-methyl-1H-indole); 0/3-3'-isoxazole-3,5-diylbis(5-methoxy-1-methyl-1H-indole); 0/Antineoplastic Agents; 0/Furans; 0/Indoles; 0/Isoxazoles |
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