| Synthesis and antituberculosis activity of new fatty acid amides. | |
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MedLine Citation:
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PMID: 20667727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This work reports the synthesis of new fatty acid amides from C16:0, 18:0, 18:1, 18:1 (OH), and 18:2 fatty acids families with cyclic and acyclic amines and demonstrate for the first time the activity of these compounds as antituberculosis agents against Mycobacterium tuberculosis H(37)Rv, M. tuberculosis rifampicin resistance (ATCC 35338), and M. tuberculosis isoniazid resistance (ATCC 35822). The fatty acid amides derivate from ricinoleic acid were the most potent one among a series of tested compounds, with a MIC 6.25 microg/mL for resistance strains. |
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Authors:
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Caroline Da Ros Montes D'Oca; Tatiane Coelho; Tamara Germani Marinho; Carolina Rosa Lopes Hack; Rodrigo da Costa Duarte; Pedro Almeida da Silva; Marcelo Gonçalves Montes D'Oca |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-07 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 20 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 5255-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Laboratório Kolbe de Síntese Orgânica, Escola de Química e Alimentos, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amides
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chemical synthesis*,
chemistry,
pharmacology* Antitubercular Agents / chemical synthesis* Fatty Acids / chemistry* Microbial Sensitivity Tests Mycobacterium tuberculosis / drug effects Spectrum Analysis / methods |
| Chemical | |
Reg. No./Substance:
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0/Amides; 0/Antitubercular Agents; 0/Fatty Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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