Document Detail


Synthesis and antiproliferative activity of some novel derivatives of diospyrin, a plant-derived naphthoquinonoid.
MedLine Citation:
PMID:  17400463     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Derivatisation of diospyrin, a bisnaphthoquinonoid isolated from Diospyros montana Roxb., led to the modification of its inhibitory activity, in vitro, towards a murine tumour model, Ehrlich ascites carcinoma (EAC), and two human cancer cell lines, viz., malignant skin melanoma (A375) and epidermoid laryngeal carcinoma (Hep2). Among the novel derivatives, an epoxide exhibited the maximum antiproliferative activity (IC(50) values in the range of 0.03-0.21 microM) and a comparatively lower toxicity (IC(50) approximately 98 microM) in normal human peripheral blood mononuclear cells (PBMC). This compound might provide a novel 'lead' for the development of clinically effective antiproliferative agents against cancer.
Authors:
Madhushree Das Sarma; Rina Ghosh; Amarendra Patra; Banasri Hazra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-03-18
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  15     ISSN:  0968-0896     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-04-30     Completed Date:  2007-07-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  3672-7     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / chemical synthesis,  chemistry*,  pharmacology*
Cell Proliferation / drug effects*
Diospyros / chemistry
Disease Models, Animal
Humans
Inhibitory Concentration 50
Leukocytes, Mononuclear / drug effects
Mice
Naphthoquinones / chemical synthesis,  chemistry*,  pharmacology*
Plant Bark / chemistry
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Naphthoquinones; 28164-57-0/diospyrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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