| Synthesis and antiproliferative activity of some novel derivatives of diospyrin, a plant-derived naphthoquinonoid. | |
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MedLine Citation:
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PMID: 17400463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Derivatisation of diospyrin, a bisnaphthoquinonoid isolated from Diospyros montana Roxb., led to the modification of its inhibitory activity, in vitro, towards a murine tumour model, Ehrlich ascites carcinoma (EAC), and two human cancer cell lines, viz., malignant skin melanoma (A375) and epidermoid laryngeal carcinoma (Hep2). Among the novel derivatives, an epoxide exhibited the maximum antiproliferative activity (IC(50) values in the range of 0.03-0.21 microM) and a comparatively lower toxicity (IC(50) approximately 98 microM) in normal human peripheral blood mononuclear cells (PBMC). This compound might provide a novel 'lead' for the development of clinically effective antiproliferative agents against cancer. |
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Authors:
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Madhushree Das Sarma; Rina Ghosh; Amarendra Patra; Banasri Hazra |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-18 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 15 ISSN: 0968-0896 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-04-30 Completed Date: 2007-07-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 3672-7 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / chemical synthesis, chemistry*, pharmacology* Cell Proliferation / drug effects* Diospyros / chemistry Disease Models, Animal Humans Inhibitory Concentration 50 Leukocytes, Mononuclear / drug effects Mice Naphthoquinones / chemical synthesis, chemistry*, pharmacology* Plant Bark / chemistry Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Naphthoquinones; 28164-57-0/diospyrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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