Document Detail

Synthesis, antiplatelet and in silico evaluations of novel N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides.
MedLine Citation:
PMID:  19380229     Owner:  NLM     Status:  MEDLINE    
This paper describes the synthesis, antiplatelet and theoretical evaluations of 10 N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides (2a-j). These compounds were synthesized, characterized and screened for their in vitro antiplatelet profile against human platelet aggregation using arachidonic acid, adrenaline and ADP as agonists. Among NAH derivatives 2a-j, the compounds 2a, 2c, 2e, 2g and 2h were the most promising molecules with significant antiplatelet activity.
Alessandro K Jordão; Vitor F Ferreira; Emerson S Lima; Maria C B V de Souza; Eduardo C L Carlos; Helena C Castro; Reinaldo B Geraldo; Carlos R Rodrigues; Maria C B Almeida; Anna C Cunha
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-01
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  17     ISSN:  1464-3391     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-06     Completed Date:  2009-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  3713-9     Citation Subset:  IM    
Universidade Federal Fluminense, Departamento de Química Orgânica, Outeiro de São João Batista, s/n degrees , Niterói, 24020-141 Rio de Janeiro, Brazil.
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MeSH Terms
Hydrazines / chemical synthesis*,  chemistry,  pharmacology
Platelet Aggregation / drug effects
Platelet Aggregation Inhibitors / chemical synthesis*,  chemistry,  pharmacology
Structure-Activity Relationship
Triazoles / chemical synthesis*,  chemistry,  pharmacology
Reg. No./Substance:
0/Hydrazines; 0/Platelet Aggregation Inhibitors; 0/Triazoles

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