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Synthesis and antinociceptive activity of some substituted-{5-[2-(1,2,3,4-tetrahydrocarbazol-9-yl)ethyl]tetrazol-1-yl}alkanones.
MedLine Citation:
PMID:  16169128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twelve different derivatives of substituted-{5-[2-(1,2,3,4-tetrahydrocarbazol-9-yl)ethyl]tetrazol-1-yl}alkanones (3-14) were synthesized by reacting 9-[2-(1H-tetrazol-5-yl)-ethyl]-2,3,4,9-tetrahydro-1H-carbazole (2) and the appropriate acid chlorides. 9-[2-(1H-tetrazol-5-yl) ethyl]-2,3,4,9-tetrahydro-1H-carbazole (2) was synthesized by reacting 3-(1,2,3,4-tetrahydrocarbazol-9-yl) propionitrile (1) with sodium azide and ammonium chloride. The chemical structures were confirmed by means of IR, 1H-NMR, mass spectra and elemental analysis. The compounds were screened for antinociceptive activity by acetic acid induced writhing method and hot plate method. 1-Phenyl-2-{5-[2-(1,2,3,4-tetrahydrocarbazol-9-yl)ethyl]tetrazol-1-yl}ethanone (13) was found to be the most active compound of the series.
Authors:
A Rajasekaran; P P Thampi
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Publication Detail:
Type:  Journal Article     Date:  2005-09-15
Journal Detail:
Title:  European journal of medicinal chemistry     Volume:  40     ISSN:  0223-5234     ISO Abbreviation:  Eur J Med Chem     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-18     Completed Date:  2006-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0420510     Medline TA:  Eur J Med Chem     Country:  France    
Other Details:
Languages:  eng     Pagination:  1359-64     Citation Subset:  IM    
Affiliation:
Medicinal Chemistry R & D Laboratory, Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil 626 190, Tamil Nadu, India. rsekaran2001in@yahoo.co.in
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MeSH Terms
Descriptor/Qualifier:
Acetic Acid / chemistry
Analgesics / administration & dosage,  chemical synthesis*,  pharmacology*
Animals
Drug Evaluation, Preclinical
Ketones / administration & dosage,  chemical synthesis*,  pharmacology*
Mice
Molecular Structure
Pain / chemically induced,  prevention & control*
Pain Measurement / drug effects
Chemical
Reg. No./Substance:
0/Analgesics; 0/Ketones; 64-19-7/Acetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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