Document Detail


Synthesis and antimicrobial evaluation of new phenoxyacetamide derivatives.
MedLine Citation:
PMID:  12064055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
New N-(5-methylisoxazol-3-yl)-2 or 3 or 4-(phenoxyacetamido)benzamides 6a-t were synthesized and tested for their in vitro antimicrobial activity against gram positive (Staphylococcus aureus ATCC 25923) and gram negative (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853) bacteria as well as fungi (Candida albicans ATCC 10231, Candida tropicalis ATCC 13803 and Cryptococcus neoformans ATCC 90112). Compounds 6 were devoid of antibacterial as well as antifungal activities at maximum tested concentrations of 50 micrograms/ml for bacteria and 100 micrograms/ml for yeast.
Authors:
D Raffa; O Migliara; G Daidone; B Maggio; D Schillaci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bollettino chimico farmaceutico     Volume:  141     ISSN:  0006-6648     ISO Abbreviation:  Boll Chim Farm     Publication Date:    2002 Jan-Feb
Date Detail:
Created Date:  2002-06-14     Completed Date:  2002-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372534     Medline TA:  Boll Chim Farm     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  3-7     Citation Subset:  IM    
Affiliation:
Università degli Studi di Palermo, Dipartimento di Chimica e Tecnologie Farmaceutiche, via Archirafi 32, 90123 Palermo, Italy.
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MeSH Terms
Descriptor/Qualifier:
Acetamides / chemical synthesis*,  pharmacology
Anti-Bacterial Agents
Anti-Infective Agents / chemical synthesis*,  pharmacology*
Bacteria / drug effects*
Fungi / drug effects*
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Indicators and Reagents
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Phenyl Ethers / chemical synthesis*,  pharmacology
Chemical
Reg. No./Substance:
0/Acetamides; 0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Indicators and Reagents; 0/Phenyl Ethers

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