Document Detail


Synthesis and antimicrobial activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazo[2,1-b]thiazole moiety.
MedLine Citation:
PMID:  19939519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of 4-alkyl/aryl-2,4-dihydro-5-((6-(4-bromophenyl)imidazo[2,1-b]thiazol-3-yl)methyl)-3H-1,2,4-triazole-3-thiones (3a-i) and 2-alkyl/arylamino-5-((6-(4-bromophenyl)imidazo[2,1-b]thiazol-3-yl)methyl)-1,3,4-thiadiazoles (4a-c) were synthesized starting from 6-(4-bromophenyl)imidazo[2,1-b]thiazole-3-acetic acid hydrazide. The newly synthesized compounds were characterized by IR, (1)H NMR, mass and elemental analysis. All compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by the microbroth dilution technique. The compounds were also evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv (ATCC 27294). The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities.
Authors:
Nuray Ulusoy G?zeldemirci; Omer K???kbasmaci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-16
Journal Detail:
Title:  European journal of medicinal chemistry     Volume:  45     ISSN:  1768-3254     ISO Abbreviation:  Eur J Med Chem     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0420510     Medline TA:  Eur J Med Chem     Country:  France    
Other Details:
Languages:  eng     Pagination:  63-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Masson SAS. All rights reserved.
Affiliation:
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey. nulusoy@istanbul.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Anti-Infective Agents / chemical synthesis,  chemistry*,  pharmacology*
Fungi / drug effects
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects
Oxazines
Radiometry
Thiadiazoles / chemical synthesis,  chemistry*,  pharmacology*
Triazoles / chemical synthesis,  chemistry*,  pharmacology*
Xanthenes
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Oxazines; 0/Thiadiazoles; 0/Triazoles; 0/Xanthenes; 288-88-0/1,2,4-triazole; 289-06-5/1,3,4-thiadiazole; 550-82-3/resazurin

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