Document Detail

Synthesis, antimicrobial activity and bleaching effect of some reaction products of 4-oxo-4H-benzopyran-3-carboxaldehydes with aminobenzothiazoles and hydrazides.
MedLine Citation:
PMID:  9639869     Owner:  NLM     Status:  MEDLINE    
The synthesis of the biologically active novel systems derived from reaction of 3-formylchromones with three types of amino derivatives, 6-R2-2-aminobenzothiazoles, 6-amino-2-R3-thiobenzothiazoles and hydrazide derivatives (derived from cyanoacetic, isonicotine, salicylic and gallic acids) was carried out. The structures of the prepared compounds have been proved by elemental analysis, 1H NMR and IR spectra. Antimicrobial activity was studied against the following microorganisms--bacteria G+ (Staphylococcus aureus 29/58, Bacillus subtilis 18/66), G- (Escherichia coli 326/71, Pseudomonas aeruginosa); yeasts: Candida albicans, Saccharomyces cerevisiae; moulds: Microsporum gypseum, Aspergillus niger, Scopulariopsis brevicaulis; and against typical and atypical mycobacteria: Mycobacterium tuberculosis (H37Rv), Mycobacterium kansasii (PFG 8), Mycobacterium avium (My 80/72), Mycobacterium fortuitum (1021). The hereditary bleaching effect on the plastid system of Euglena gracilis, a unique phenomenon of the biological activity of chromone derivatives, is reported. The bleaching test on E. gracilis is used for detecting extranuclear mutations.
H M el-Shaaer; P Foltínová; M Lácová; J Chovancová; H Stankovicová
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Farmaco (Società chimica italiana : 1989)     Volume:  53     ISSN:  0014-827X     ISO Abbreviation:  Farmaco     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-08-03     Completed Date:  1998-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912641     Medline TA:  Farmaco     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  224-32     Citation Subset:  IM    
Department of Chemistry, Faculty of Education, Ain Shams University, Cairo, Egypt.
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MeSH Terms
Anti-Bacterial Agents / chemical synthesis,  pharmacology*
Antifungal Agents / chemical synthesis,  pharmacology*
Chromones / chemical synthesis,  pharmacology*
Hydrazines / chemistry*
Molecular Structure
Thiazoles / chemistry*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Chromones; 0/Hydrazines; 0/Thiazoles

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