| Synthesis and antifungal activity of 5-arylamino-4,7-dioxobenzo[b]thiophenes. | |
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MedLine Citation:
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PMID: 15863328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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5-Arylamino-4,7-dioxobenzo[b]thiophenes 3-6 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 5-Arylamino-6-chloro-2-(methoxycarbonyl)-4,7-dioxobenzo[b]thiophenes 5 showed, in general, more potent antifungal activity against Candida species than the other 4,7-dioxobenzo[b]thiophenes 3, 4 and 6. The results suggest that 5-arylamino-4,7-dioxobenzo[b]thiophenes would be potent antifungal agents. |
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Authors:
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Chung-Kyu Ryu; Su-Kyung Lee; Ja-Young Han; Ok-Jai Jung; Jung Yoon Lee; Seong Hee Jeong |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 15 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-02 Completed Date: 2005-10-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 2617-20 Citation Subset: IM |
Affiliation:
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College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, South Korea. ckryu@mm.ewha.ac.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antifungal Agents
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chemical synthesis*,
chemistry,
pharmacology* Structure-Activity Relationship Thiophenes / chemical synthesis*, chemistry, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Thiophenes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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