| Synthesis and antidiabetic activity of some new chromonyl-2,4-thiazolidinediones. | |
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MedLine Citation:
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PMID: 20687791 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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A series of chromonyl-2,4-thiazolidinediones/imidazolidinediones/2-thioxo-imidazolidine-4-ones (IIIa-i, IVa-i) was prepared by Knoevenagel reaction of 2,4-thiazolidinedione/2,4-imidazolidinedione/2-thioxo-imidazolidine-4-one (IIa-c) with 2/3-formyl chromone (Ia-b) and then alkylation with methyl/ethyl iodide. The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds ıVb and ıVc (at lower concentration, 1 μg/mL) were able to increase insulin release in the presence of 5.6 mmol/L glucose." should be written as "Compounds IVb and IVc (at lower concentration, 1 µg/mL) and also IIId and IIIg (at higher concentration) were able to increase insulin release in the presence of 5.6 mmol/L glucose. Compounds ıVb and ıVc (at lower concentration, 1 μg/mL) were able to increase insulin release in the presence of 5.6 mmol/L glucose. |
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Authors:
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Meltem Ceylan-Ünlüsoy; Eugen J Verspohl; Rahmiye Ertan |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-05 |
Journal Detail:
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Title: Journal of enzyme inhibition and medicinal chemistry Volume: 25 ISSN: 1475-6374 ISO Abbreviation: J Enzyme Inhib Med Chem Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101150203 Medline TA: J Enzyme Inhib Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 784-9 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandoğan, Ankara, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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